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Fig. 5 | Human Genomics

Fig. 5

From: Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network

Fig. 5

Protein–protein interaction (PPI) network of DSCR9 co-expression genes. a DSCR9 Network structure visualized with Cytoscape. Each node represented one gene. Nodes with red border represented co-expressed genes involved in neuroactive ligand-receptor interaction pathway. Nodes filled with light yellow color represented co-expressed genes functioned in calcium signaling pathway, while nodes shaped in hexagonal represent co-expressed genes related to neuronal system. Orange lines show PPI between those highly correlated co-expressed genes of DSCR9. Red lines represented potential relationships between DSCR9 and its targets. b The core DSCR targeted genes in the PPI network were listed with their gene symbols and weights. Numbers in the bars showed the interaction weight of the corresponding genes in DSCR9 network (Fig. 4a). Orange-colored bars indicated that the corresponding genes were members of the neuro-related pathways

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Human Genomics

ISSN: 1479-7364