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Fig. 1 | Human Genomics

Fig. 1

From: Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma

Fig. 1

Distribution of potential MAR/SAR sites predicted in the ABL gene. The ABL genomic map from nucleotide positions 601-174330 is illustrated above [Ensembl:ENSG00000097007]. The locations of exons 1 to 11 are shown. Green boxes represent the three previously reported patient breakpoints cluster regions which are designated as BCRA, BCRB and BCRC. Yellow box shows the previously biochemically extracted MAR/SAR which is designated as SAR1 [77]. Yellow arrows represent the potential MAR/SARs predicted by MRS. Clusters of more than one MRS within close proximity are regarded as a single potential MAR/SAR site. For instance, there were two MRSs predicted in BCRB, however, they were regarded as a single potential MAR/SAR site (MAR/SAR 3) because they were found in close proximity. There was one MAR/SAR site (MAR/SAR 9) predicted in the experimentally isolated SAR1

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