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Fig. 10 | Human Genomics

Fig. 10

From: Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma

Fig. 10

A potential model for the shift translocation of the LHFPL3 gene. During oxidative stress-induced apoptosis, chromosomal breakages occur within both the LHFPL3 (located at chromosome 7q22) and ABL (located at chromosome 9q34) genes. Following that, interstitial deletion occurs within the LHFPL3 gene. When the cells try to survive apoptosis, DNA repair takes place. By utilising the region of microhomology, TGCC, that was found at the breakpoint junctions of both the LHFPL3 and ABL genes, the two DNA ends were joined. Subsequently, cells that survive apoptosis may carry the ABL gene with the shift translocation of a segment of the LHFPL3 gene

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