A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa

Table 1 Two-point LOD scores of markers around 4q31.21-q32.1

Marker	CM	Mb	0	0.01	0.05	0.1	0.2	0.3	0.4	Z _max	θ _max
D4S1615	128.31	128.21	− 3.81	− 2.00	− 0.36	0.15	0.30	0.17	0.03	0.30	0.20
D4S429	131.00	133.11	− 2.05	− 1.19	− 0.08	0.25	0.31	0.17	0.04	0.31	0.20
D4S1575	132.05	134.79	4.90	4.80	4.40	3.89	2.82	1.72	4.90	4.90	0.00
D4S3039	132.72	135.96	1.26	2.78	3.10	2.93	2.24	1.42	3.10	3.10	0.05
D4S1576	135.57	138.99	− 5.19	− 2.27	− 1.14	− 0.74	− 0.38	− 0.17	− 0.17	− 0.17	0.30
D4S1579	140.64	140.73	− ∞	− 0.01	1.01	1.17	0.89	0.42	1.17	1.17	0.10
D4S2939	142.24	141.15	− ∞	− 0.92	1.99	2.13	1.74	1.06	0.36	2.13	0.09
D4S424	144.56	142.20	− ∞	− 3.69	− 0.19	0.30	0.51	0.39	0.19	0.51	0.20
D4S2998	145.98	145.57	5.40	5.39	4.89	4.36	3.25	2.08	0.94	5.40	0.00
D4S1586	147.06	146.78	5.13	5.12	4.61	4.08	2.99	1.88	0.83	5.13	0.00
D4S3008	152.98	150.30	2.72	2.72	2.54	2.29	1.70	1.04	0.43	2.72	0.00
D4S1548	153.51	152.14	1.74	1.74	1.63	1.46	1.05	0.62	0.25	1.74	0.00
D4S3021	154.63	154.94	4.08	4.08	3.77	3.39	2.52	1.57	0.68	4.08	0.00
D4S3049	155.19	154.77	4.54	4.53	4.03	3.51	2.41	1.29	0.35	4.54	0.00
D4S2976	155.31	155.80	3.99	3.98	3.57	3.15	2.29	1.45	0.66	3.99	0.00
LRAT c.541-15T>G		155.67	6.57	6.47	6.04	5.48	4.28	2.94	1.49	6.57	0.00
D4S2934	155.41	154.05	4.89	4.88	4.40	3.90	2.86	1.81	0.83	4.89	0.00
D4S2918	157.99	160.33	2.77	2.76	2.45	2.14	1.51	0.91	0.39	2.77	0.00
D4S1585	157.99	157.51	3.05	3.04	2.74	2.42	1.78	1.13	0.52	3.05	0.00
D4S2982	158.65	161.09	− ∞	0.98	2.30	2.20	1.71	1.11	0.52	2.30	0.05

ISSN: 1479-7364