Fig. 4

SNV mutations in HeLa cells. a Numbers of base positions of different genotypes on day 5, and their changes observed on day 10 relative to day 5 (Δ10–5), and on day 14 relative to day 5 (Δ14–5). b Patch diagrams tracing the mutated changes of MM, mm, and Mm residues of day 5 DNA in day 10 DNA and day 14 DNA. LOHs showing large lineage effects are highlighted by yellow triangles. c Mutational profiles for the changes indicated in part b between day 5 and day 10 DNAs (∆10–5) and between day 10 and day 14 DNAs (∆14–10). For each vertical bar in the ∆10–5 tier, the solid segment represents SNVs that were subsequently reversed in the ∆14–10 tier, and the open segment represents the unreversed SNVs