Fig. 6

Properties of SNVs in N-T-M trio samples. a Mutational profiles for the ∆TN and ∆MT SNV changes as numerically indicated in the patch diagrams in Fig. 5b. In each vertical bar in the ∆TN tier, the solid segment represents the SNVs that were reversed in the ∆MT tier, whereas the open segment indicates the unreversed SNVs. b Zonal distribution and replication timing of the SNVs in the ∆TN tier and the ∆MT tier in the five case groups. Left panels: zonal classification of SNV (GOH and LOH) sites determined as described [35]. Right panels: replication timing scores derived from ENCODE at UCSC based on the “Repli-chip” method [52] (see Figs. 1 and 5 for abbreviations)