Fig. 6
From: Forward and reverse mutations in stages of cancer development
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40246-018-0170-6/MediaObjects/40246_2018_170_Fig6_HTML.png)
Properties of SNVs in N-T-M trio samples. a Mutational profiles for the ∆TN and ∆MT SNV changes as numerically indicated in the patch diagrams in Fig. 5b. In each vertical bar in the ∆TN tier, the solid segment represents the SNVs that were reversed in the ∆MT tier, whereas the open segment indicates the unreversed SNVs. b Zonal distribution and replication timing of the SNVs in the ∆TN tier and the ∆MT tier in the five case groups. Left panels: zonal classification of SNV (GOH and LOH) sites determined as described [35]. Right panels: replication timing scores derived from ENCODE at UCSC based on the “Repli-chip” method [52] (see Figs. 1 and 5 for abbreviations)