Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes

Table 2 Binary logistic regression analysis using type 2 diabetes as dependent variable

	Unadjusted		Adjusted for age and BMI		Adjusted for HOMA-IR		Adjusted for senescence markers (GLB, P53, P21, P16, and TL)		Adjusted for inflammatory markers (TNF-α, IL6, MCP1, IL1-β, and SOCS3)
	β	p	β	p	β	p	β	p	β	p
PLUTO	1.721	0.005	1.827	0.003	23.673	0.063	1.848	0.210	2.204	0.025
ENST00000550337.1	2.023	0.004	1.925	0.013	2.984	0.132	33.73	0.184	4.026	0.038
CDKN2BAS1	3.173	0.006	4.925	0.002	4.188	0.068	2.741	0.100	2.995	0.044
lincRNA-p21	1.867	0.021	1.970	0.033	3.492	0.096	2.283	0.311	6.395	0.013
HOTAIR	4.348	0.001	5.256	0.001	2.556	0.342	1.651	0.524	8.125	0.015
GAS5	10.642	0.001	14.054	0.001	20.820	0.226	22.512	0.128	12.214	0.069
XIST	0.388	0.003	3.824	0.004	3.677	0.145	2.318	0.386	3.166	0.024
PANDA	7.960	0.003	15.737	0.002	30.052	0.041	27.726	0.151	3.548	0.253
NBR2	2.045	0.041	1.728	0.159	1.496	0.522	1.869	0.443	2.675	0.141
RNCR3	1.464	0.144	1.650	0.065	1.795	0.394	1.582	0.410	1.740	0.225
MIAT	6.591	0.002	5.293	0.012	8.383	0.235	8.753	0.181	5.388	0.118
MEG3	5.669	0.013	6.444	0.017	17.060	0.141	12.830	0.063	57.903	0.023
LET	7.116	0.014	5.806	0.036	6.736	0.068	4.399	0.534	2.079	0.584
MALAT1	9.945	0.008	5.156	0.046	4.712	0.193	12.858	0.343	33.033	0.086
GM4419	2.468	0.104	2.142	0.242	3.254	0.232	4.832	0.293	1.937	0.433
SALRNA1	0.161	0.013	0.114	0.009	0.029	0.127	0.072	0.057	0.092	0.100
THRIL	0.047	0.001	0.529	0.001	0.013	0.084	0.063	0.139	0.333	0.271

ISSN: 1479-7364