Table 5 Association of tumors characteristics with ancestral markers among patients with CRC
From: Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos
European ancestrya | African ancestrya | Amerindian ancestrya | ||||
|---|---|---|---|---|---|---|
Tumor characteristicb | OR unadjusted (95% CI) | OR adjustedc (95% CI) | OR unadjusted (95% CI) | OR adjustedc (95% CI) | OR unadjusted (95% CI) | OR adjustedc (95% CI) |
Tumor location | ||||||
Proximal | 0.84 (0.51–1.39) | 0.91 (0.53–1.58) | 0.80 (0.48–1.31) | 0.83 (0.48–1.45) | 1.39 (0.84–2.32) | 1.27 (0.73–2.23) |
Distal | 1.13 (0.70–1.82) | 1.13 (0.66–1.91) | 1.02 (0.63–1.64) | 1.37 (0.80–2.35) | 1.69 (1.03–2.75) | 1.32 (0.78–2.26) |
Rectum | 0.85 (0.60–1.21) | 0.88 (0.60–1.31) | 1.40 (0.98–1.99) | 1.55 (1.05–2.31) | 0.87 (0.62–1.23) | 0.75 (0.51–1.11) |
Tumor stage | ||||||
0/I/II | 0.89 (0.60–1.32) | 0.88 (0.56–1.38) | 1.14 (0.77–1.70) | 1.43 (0.91–2.25) | 1.28 (0.86–1.90) | 1.04 (0.66–1.63) |
III/IV | 1.03 (0.67–1.58) | 1.15 (0.72–1.83) | 0.94 (0.61–1.4) | 0.93 (0.58–1.48) | 1.42 (0.92–2.20) | 1.34 (0.83–2.14) |
Other/unknown | 1.35 (0.66–2.79) | 1.53 (0.72–3.23) | 1.13 (0.55–2.32) | 1.07 (0.51–2.26) | 1.22 (0.59–2.52) | 1.06 (0.50–2.22) |
Tumor differentiation | ||||||
High | 1.21 (0.70–2.10) | 1.25 (0.68–2.29) | 0.75 (0.43–1.31) | 0.90 (0.49–1.66) | 1.35 (0.77–2.35) | 1.16 (0.63–2.14) |
Moderate/low | 0.91 (0.65–1.28) | 0.95 (0.64–1.39) | 1.15 (0.82–1.62) | 1.20 (0.82–1.77) | 1.25 (0.88–1.76) | 1.11 (0.75–1.63) |
Microsatellite status | ||||||
Stable | 1.08 (0.70–1.66) | 1.02 (0.63–1.65) | 1.01 (0.66–1.55) | 1.23 (0.76–2.00) | 1.14 (0.74–1.75) | 1.08 (0.67–1.75) |
Low/high | 4.23 (0.47–38.19) | 4.38 (0.48–36.62) | 0.25 (0.03–2.23) | 0.52 (0.03–2.25) | 1.43 (0.24–8.65) | 1.39 (0.23–8.46) |
CIMP status | ||||||
None | 0.53 (0.13–2.14) | 0.57 (0.14–2.33) | 3.47 (0.71–16.88) | 3.72 (0.74–18.72) | 0.48 (0.12–1.93) | 0.42 (0.10–1.74) |
Low | 0.81 (0.49–1.33) | 0.85 (0.49–1.47) | 1.37 (0.83–2.26) | 1.50 (0.86–2.60) | 0.81 (0.49–1.33) | 0.83 (0.48–1.44) |
KRAS mutation status | ||||||
Wild type | 1.18 (0.72–1.93) | 1.23 (0.72–2.10) | 0.99 (0.60–1.62) | 1.11 (0.65–1.90) | 1.31 (0.80–2.16) | 1.20 (0.70–2.07) |
Mutated | 0.89 (0.45–1.78) | 0.86 (0.42–1.75) | 1.18 (0.60–2.35) | 1.17 (0.57–2.40) | 0.49 (0.24–1.02) | 0.49 (0.23–1.02) |
BRAF mutation status | ||||||
Wild type | 0.98 (0.63–1.51) | 1.01 (0.62–1.63) | 0.99 (0.64–1.54) | 1.02 (0.63–1.65) | 0.94 (0.61–1.47) | 0.92 (0.57–1.49) |
Mutated | 3.17 (0.63–15.91) | 2.68 (0.51–14.10) | 2.97 (0.59–14.89) | 6.36 (0.74–54.37) | 0.31 (0.06–1.58) | 0.13 (0.02–1.13) |