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Table 5 Association of tumors characteristics with ancestral markers among patients with CRC

From: Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

  European ancestrya African ancestrya Amerindian ancestrya
Tumor characteristicb OR unadjusted
(95% CI)
OR adjustedc
(95% CI)
OR unadjusted (95% CI) OR adjustedc
(95% CI)
OR unadjusted (95% CI) OR adjustedc
(95% CI)
Tumor location
 Proximal 0.84 (0.51–1.39) 0.91 (0.53–1.58) 0.80 (0.48–1.31) 0.83 (0.48–1.45) 1.39 (0.84–2.32) 1.27 (0.73–2.23)
 Distal 1.13 (0.70–1.82) 1.13 (0.66–1.91) 1.02 (0.63–1.64) 1.37 (0.80–2.35) 1.69 (1.03–2.75) 1.32 (0.78–2.26)
 Rectum 0.85 (0.60–1.21) 0.88 (0.60–1.31) 1.40 (0.98–1.99) 1.55 (1.05–2.31) 0.87 (0.62–1.23) 0.75 (0.51–1.11)
Tumor stage
 0/I/II 0.89 (0.60–1.32) 0.88 (0.56–1.38) 1.14 (0.77–1.70) 1.43 (0.91–2.25) 1.28 (0.86–1.90) 1.04 (0.66–1.63)
 III/IV 1.03 (0.67–1.58) 1.15 (0.72–1.83) 0.94 (0.61–1.4) 0.93 (0.58–1.48) 1.42 (0.92–2.20) 1.34 (0.83–2.14)
 Other/unknown 1.35 (0.66–2.79) 1.53 (0.72–3.23) 1.13 (0.55–2.32) 1.07 (0.51–2.26) 1.22 (0.59–2.52) 1.06 (0.50–2.22)
Tumor differentiation
 High 1.21 (0.70–2.10) 1.25 (0.68–2.29) 0.75 (0.43–1.31) 0.90 (0.49–1.66) 1.35 (0.77–2.35) 1.16 (0.63–2.14)
 Moderate/low 0.91 (0.65–1.28) 0.95 (0.64–1.39) 1.15 (0.82–1.62) 1.20 (0.82–1.77) 1.25 (0.88–1.76) 1.11 (0.75–1.63)
Microsatellite status
 Stable 1.08 (0.70–1.66) 1.02 (0.63–1.65) 1.01 (0.66–1.55) 1.23 (0.76–2.00) 1.14 (0.74–1.75) 1.08 (0.67–1.75)
 Low/high 4.23 (0.47–38.19) 4.38 (0.48–36.62) 0.25 (0.03–2.23) 0.52 (0.03–2.25) 1.43 (0.24–8.65) 1.39 (0.23–8.46)
CIMP status
 None 0.53 (0.13–2.14) 0.57 (0.14–2.33) 3.47 (0.71–16.88) 3.72 (0.74–18.72) 0.48 (0.12–1.93) 0.42 (0.10–1.74)
 Low 0.81 (0.49–1.33) 0.85 (0.49–1.47) 1.37 (0.83–2.26) 1.50 (0.86–2.60) 0.81 (0.49–1.33) 0.83 (0.48–1.44)
KRAS mutation status
 Wild type 1.18 (0.72–1.93) 1.23 (0.72–2.10) 0.99 (0.60–1.62) 1.11 (0.65–1.90) 1.31 (0.80–2.16) 1.20 (0.70–2.07)
 Mutated 0.89 (0.45–1.78) 0.86 (0.42–1.75) 1.18 (0.60–2.35) 1.17 (0.57–2.40) 0.49 (0.24–1.02) 0.49 (0.23–1.02)
BRAF mutation status
 Wild type 0.98 (0.63–1.51) 1.01 (0.62–1.63) 0.99 (0.64–1.54) 1.02 (0.63–1.65) 0.94 (0.61–1.47) 0.92 (0.57–1.49)
 Mutated 3.17 (0.63–15.91) 2.68 (0.51–14.10) 2.97 (0.59–14.89) 6.36 (0.74–54.37) 0.31 (0.06–1.58) 0.13 (0.02–1.13)
  1. aDichotomous variables were analyzed the median value of each ancestry marker among controls as a cut-off
  2. bControls as reference category
  3. cPOR’s adjusted by age at recruitment, gender, ever smoked, current drinking, and BMI