|  | Responders (n = 54) | Non-responders (n = 91) | ||||||
---|---|---|---|---|---|---|---|---|---|
ARMS2 rs10490924 |  | GG (n = 16) | GT (n = 22) | TT (n = 16) | P c | GG (n = 5) | GT (n = 35) | TT (n = 51) | P c |
 Age |  | 66.68 ± 7.88 | 68.77 ± 6.97 | 69.38 ± 3.70 | 0.469 | 65.80 ± 5.81 | 71.34 ± 8.12 | 68.71 ± 8.07 | 0.187 |
 Smoking |  | 5 (31.3) | 8 (36.4) | 2 (12.5) | 0.251 | 2 (40.0) | 16 (45.7) | 17 (33.3) | 0.509 |
 Mean BCVA (logMAR)a | Baseline | 0.58 ± 0.27 | 0.67 ± 0.27 | 0.72 ± 0.28 | 0.328b | 0.64 ± 0.35 | 0.49 ± 0.26 | 0.51 ± 0.22 | 0.509b |
3 months | 0.51 ± 0.25 | 0.54 ± 0.27 | 0.67 ± 0.36 | 0.253 | 0.82 ± 0.26 | 0.61 ± 0.25 | 0.59 ± 0.23 | 0.191b | |
6 months | 0.33 ± 0.19 | 0.48 ± 0.26 | 0.45 ± 0.22 | 0.119b | 0.82 ± 0.26 | 0.65 ± 0.28 | 0.67 ± 0.28 | 0.420b | |
 Mean CRT (μM)a | Baseline | 432.7 ± 107.73 | 490.5 ± 159.19 | 514.1 ± 180.79 | 0.307 | 370.2 ± 192.43 | 324.7 ± 86.96 | 324.1 ± 73.19 | 0.525 |
3 months | 327.1 ± 88.53 | 367.3 ± 138.55 | 342.5 ± 103.94 | 0.562 | 397.8 ± 320.3 | 347.8 ± 128.34 | 357.1 ± 90.37 | 0.406b | |
6 months | 307.7 ± 85.37 | 323.6 ± 103.78 | 332.3 ± 108.36 | 0.78 | 374.4 ± 269.59 | 348.7 ± 143.92 | 421.4 ± 127.03 | 0.072 | |
 Changes in BCVA (logMAR)a | 3 months | − 0.07 ± 0.13 | − 0.13 ± 0.22 | − 0.05 ± 0.23 | 0.462b | 0.18 ± 0.30 | 0.12 ± 0.21 | 0.08 ± 0.17 | 0.651b |
6 months | − 0.24 ± 0.16 | − 0.19 ± 0.24 | − 0.26 ± 0.23 | 0.593 | 0.18 ± 0.30 | 0.16 ± 0.21 | 0.15 ± 0.24 | 0.960b | |
 Changes in CRT (μM)a | 3 months | − 105.6 ± 59.04 | − 123.2 ± 122.81 | − 171.6 ± 188.21 | 0.349 | 27.6 ± 136.82 | 23.1 ± 92.01 | 33.0 ± 72.25 | 0.865 |
6 months | − 125.0 ± 52.98 | − 166.8 ± 135.36 | − 181.8 ± 176.76 | 0.454 | 4.2 ± 85.65 | 23.9 ± 94.53 | 97.3 ± 128.36 | 0.009* | |
 Logistic regressiond | Co-dominant e | P < 0.001*, OR = 3.15, 95% CI (1.75–5.67) |  |  |  |  | |||
HTRA1 rs11200638 |  | GG (n = 15) | GA (n = 21) | AA (n = 18) |  | GG (n = 4) | GA (n = 26) | AA (n = 61) |  |
 Age |  | 66.53 ± 8.13 | 68.95 ± 7.07 | 69.11 ± 3.66 | 0.455 | 63.75 ± 4.11 | 70.62 ± 8.39 | 69.49 ± 8.04 | 0.286 |
 Smoking |  | 4 (26.7) | 9 (42.9) | 2 (11.1) | 0.087 | 2 (50.0) | 13 (50.0) | 20 (32.8) | 0.284 |
 Mean BCVA (logMAR)a | Baseline | 0.55 ± 0.25 | 0.69 ± 0.28 | 0.69 ± 0.27 | 0.192b | 0.73 ± 0.34 | 0.55 ± 0.26 | 0.48 ± 0.22 | 0.180b |
3 months | 0.49 ± 0.25 | 0.58 ± 0.29 | 0.62 ± 0.33 | 0.521 | 0.90 ± 0.20 | 0.63 ± 0.25 | 0.58 ± 0.23 | 0.034b* | |
6 months | 0.32 ± 0.19 | 0.48 ± 0.26 | 0.46 ± 0.22 | 0.059b | 0.90 ± 0.20 | 0.67 ± 0.25 | 0.65 ± 0.29 | 0.191b | |
 Mean CRT (μM)a | Baseline | 444.7 ± 99.74 | 487.1 ± 168.15 | 502.1 ± 174.90 | 0.556 | 382.0 ± 220.09 | 318.8 ± 80.19 | 326.7 ± 77.79 | 0.406 |
3 months | 332.4 ± 88.99 | 380.5 ± 141.31 | 323.2 ± 94.33 | 0.251 | 417.5 ± 366.34 | 339.7 ± 116.68 | 358.6 ± 102.01 | 0.519b | |
6 months | 313.4 ± 85.14 | 333.1 ± 109.14 | 314.6 ± 100.66 | 0.794 | 388.3 ± 309.23 | 348.7 ± 146.94 | 408.9 ± 130.38 | 0.212 | |
 Changes in BCVA (logMAR)a | 3 months | − 0.05 ± 0.10 | − 0.12 ± 0.23 | − 0.08 ± 0.23 | 0.735b | 0.18 ± 0.36 | 0.08 ± 0.20 | 0.10 ± 0.18 | 0.870b |
6 months | − 0.23 ± 0.16 | − 0.22 ± 0.25 | − 0.24 ± 0.22 | 0.945 | 0.18 ± 0.35 | 0.12 ± 0.18 | 0.17 ± 0.24 | 0.664b | |
 Changes in CRT (μM)a | 3 months | − 112.3 ± 54.30 | − 106.6 ± 115.37 | − 178.9 ± 183.41 | 0.191 | 35.5 ± 156.67 | 20.9 ± 73.19 | 31.9 ± 83.25 | 0.846 |
6 months | − 131.3 ± 48.17 | − 154.0 ± 135.01 | − 187.5 ± 171.50 | 0.474 | 6.3 ± 98.75 | 29.9 ± 91.8 | 82.3 ± 128.03 | 0.107 | |
 Logistic regressiond | Recessivee | P < 0.001*, OR = 4.42, 95% CI (2.11–9.25) |  |  |  |  |