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Table 1 Clinical characteristics of participants from the Affy6.0 datasets (stage 1a)

From: Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans

 

WFSM

FIND

ARIC

JHS

MESA

CARDIA

T2D-ESKD

Non-diabetic non-nephropathy

T2D-ESKD

T2D-lacking nephropathy

T2D-ESKD

Non-diabetic non-nephropathy

T2D-lacking nephropathy

Non-diabetic non-nephropathy

T2D-lacking nephropathy

Non-diabetic non-nephropathy

T2D-lacking nephropathy

Non-diabetic non-nephropathy

T2D-lacking nephropathy

N

790

891

627

299

96

1318

807

1569

343

774

278

747

165

Females (%)

63

56

54

76

65

62

63

59

68

54

53

60

66

Age (years)

62.1 ± 10.0

47.2 ± 11.8

56.84 ± 12.0

59.8 ± 11.1

68.2 ± 6.6

60.2 ± 6.1

60.3 ± 5.8

53.4 ± 11.6

59.3 ± 9.1

63.9 ± 9.2

65.6 ± 9.2

47.6 ± 5.0

49.4 ± 4.3

Age of onset of diabetes (years)

40.4 ± 11.8

–

–

–

47.3 ± 10.4

–

57.4 ± 10.8

-

44.9 ± 11.3

–

–

–

32.3 ± 7.9

Duration of diabetes prior to ESKD (years)

18.5 ± 9.6

–

–

–

20.5 ± 8.6

–

–

–

–

–

–

–

–

Duration of ESKD (years)

3.3 ± 3.6

–

–

–

0.6 ± 1.8

–

–

–

–

–

–

–

–

Fasting serum glucose (mg/dl)

193 ± 64

–

–

–

293 ± 115

105 ± 9

192 ± 94

90 ± 8

156 ± 66

98 ± 10

164 ± 59

96 ± 9

167 ± 66

eGFR (ml/min/1.73m2)

-

96.7 ± 21.3

–

–

-

78.6 ± 12.5

79.5 ± 12.6

95.5 ± 17.6

92.7 ± 18.5

78.9 ± 12.1

82.9 ± 16.0

91.1 ± 13.1

95.6 ± 13.6

Body mass index (kg/m2)

29.8 ± 7.0

30.0 ± 7.0

–

–

33.4 ± 7.3

29.2 ± 6.1

32.2 ± 6.8

31.6 ± 7.7

35.4 ± 7.7

29.8 ± 5.8

31.8 ± 6.5

–

–

  1. Categorical data expressed as percentage; continuous data as mean ± SD
  2. Abbreviations: T2D type 2 diabetes, ESKD end-stage kidney disease, N number, eGFR estimated glomerular filtration rate