Fig. 4

Heat map of MNV variant impacts. a MNV with frameshift insertion (SIFT score 0.00–1). b SNP with nonsense mutation (SIFT score 0.00–1). Worse functional impact SIFT score ranges from 0.00 represents a deleterious effect in genes to 1 represents tolerated effect in genes. Variants with scores closer to 0.00 are more confidently predicted to be deleterious. Variants with scores 0.05 to 1 are predicted to be tolerated (benign). Variants with scores very close to 1 are more confidently predicted to be tolerated. Horizontal axis represents gene order distance