Fig. 1
From: Identification of a novel long non-coding RNA within RUNX1 intron 5
RUNX1 intron 5 presents putative cis-regulatory elements that colocalize with chromosomal breakpoint regions. First, the presence of DNaseI hypersensitivity hotspots along RUNX1 intron5 was analyzed using DNase-seq data of HL-60 cells available in the ENCODE Project server (a). Then, processed data from DNase-seq experiments performed on 124 cell types, available in the server ENCODE, was analyzed to evaluate DNaseI hypersensitivity along RUNX1 intron 5 (b, left panel), a region surrounding the transcription start site (TSS) of SNRPD3 gene (b, middle panel), a gene-free region found in chromosome 1 (b, right panel), and the major-BCR (M-BCR) from BCR gene (c). In the same way, processed data from ChIP-seq experiments performed in 51 cell types, available in the server ENCODE, was analyzed to evaluate the presence of the epigenetic mark H3K4me3 within RUNX1 intron 5 (d, left panel), a region surrounding the transcription start site (TSS) of SNRPD3 gene (d, middle panel), a gene-free region found in chromosome 1 (d, right panel), and the major-BCR (M-BCR) from BCR gene (e). Each region was subdivided into 2.5 kb-modules, as indicated by roman numerals. The bars represent the number of cell types that, at least, have one hotspot of DNaseI hypersensitivity (black) or the epigenetic mark H3K4me3 (gray), in each respective module