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Table 1 Genes significantly associated with risk of multiple myeloma

From: Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Locus Gene P value N/Nindep Z-score min Z-score max Z-score mean Z-score s.d. SNP adjusting for P value after SNP adjustment
16p11.2 QPRT 1.01 × 10−7 17/8 − 2.73 3.04 − 0.59 1.63 rs13338946 0.15
16p11.2 RNF40 4.02 × 10−7 24/3 0.05 5.68 4.67 1.48 rs13338946 0.89
16p11.2 PRR14 4.28 × 10−7 2/2 − 5.38 − 0.20 − 2.79 3.66 rs13338946 0.34
16p11.2 C16orf93 8.07 × 10−7 13/5 − 5.74 − 0.34 − 4.59 1.73 rs13338946 0.24
16p11.2 RP11-2C24.5 1.54 × 10−6 5/5 − 5.64 4.43 − 0.58 3.80 rs13338946 0.73
16p11.2 PRSS53 1.71 × 10−6 16/8 − 5.19 3.68 − 1.04 2.71 rs13338946 0.79
16q23.1 RFWD3 7.71 × 10−7 34/7 − 3.41 6.35 2.51 3.26 rs7193541 0.47
17p11.2 TBC1D27 1.95 × 10−13 6/6 − 1.91 4.19 0.51 2.16 rs34562254 0.89
17p11.2 USP32P1 4.88 × 10− 13 3/3 − 7.29 2.80 −1.36 5.27 rs34562254 0.01
17p11.2 PEMT 5.65 × 10−8 14/7 − 1.74 5.43 1.36 1.93 rs34562254 0.01
22q13.1 APOBEC3C 1.10 × 10−18 21/8 − 8.93 0.24 − 4.09 2.21 rs139402 0.13
22q13.1 APOBEC3H 4.28 × 10−15 7/5 − 5.45 7.92 − 0.95 4.38 rs139402 0.76
22q13.1 FAM83F 4.65 × 10−10 11/8 − 4.25 2.56 − 0.48 2.01 rs139402 1.1 × 10−4
22q13.1 APOBEC3D 6.2 × 10−10 29/7 − 8.38 − 0.85 − 4.15 1.56 rs139402 0.04
22q13.1 APOBEC3F 5.15 × 10−9 5/4 − 6.34 6.15 1.09 5.07 rs139402 0.13
22q13.1 APOBEC3G 1.81 × 10−7 43/2 0.36 6.57 4.94 1.17 rs139402 0.17
2p23.3 KIF3C 1.65 × 10−18 6/6 − 9.40 4.35 − 1.19 4.50 rs7577599 1.4 × 10−9
2p23.3 EPT1 8.37 × 10−16 9/9 − 1.76 6.00 1.30 2.72 rs7577599 2.1 × 10−5
2p23.3 CENPO 1.48 × 10−13 12/8 − 6.60 2.22 − 0.05 2.57 rs7577599 6.1 × 10−8
2p23.3 DNMT3A 2.44 × 10−13 8/8 − 2.89 7.96 1.94 3.07 rs7577599 0.01
2p23.3 AC010150.1 2.90 × 10−13 4/4 − 0.88 7.89 1.61 4.20 rs7577599 8.9 × 10−10
2p23.3 PTGES3P2 4.46 × 10−11 7/5 − 4.23 2.03 − 2.46 2.08 rs7577599 1.1 × 10−4
2p23.3 DTNB 1.16 × 10−7 11/10 − 3.88 5.78 0.36 2.38 rs7577599 3.1 × 10−3
2p23.3 DNAJC27 1.74 × 10−7 8/8 − 0.74 4.52 1.95 1.58 rs7577599 0.11
3p22.1 ULK4 9.01 × 10−15 43/6 0.90 8.89 6.60 2.24 rs6599192 0.85
3q26.2 MYNN 7.84 × 10−13 6/6 − 7.91 1.58 − 1.66 3.32 rs10936600 0.17
3q26.2 LRRIQ4 9.63 × 10−9 3/2 − 5.94 − 0.88 − 4.25 2.92 rs10936600 0.03
3q26.2 LRRC34 3.35 × 10−8 21/2 3.97 6.47 5.12 0.66 rs10936600 0.82
3q26.2 ACTRT3 4.28 × 10−7 4/4 − 0.94 5.80 1.56 2.94 rs10936600 0.48
6q21 ATG5 1.55 × 10−12 4/4 0.93 5.89 3.72 2.41 rs9372120 0.07
7p15.3 CDCA7L 9.61 × 10−9 8/8 − 3.11 4.61 1.12 2.42 rs75341503 0.23
7q36.1 CHPF2 2.53 × 10−7 6/6 − 2.01 2.13 0.40 1.49 rs7781265 0.06
  1. Excludes associations found in the HLA region. s.d., standard deviation. Detailed are the S-MultiXcan P values for association between gene expression MM, and the corresponding Z-scores quantifying this relationship (e.g. a positive score indicates increased gene expression increases risk). N and Nindep indicate the total number of single-tissue results used for S-MultiXcan analysis and the number of independent components after singular value decomposition, respectively