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Table 1 Genes significantly associated with risk of multiple myeloma

From: Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Locus

Gene

P value

N/Nindep

Z-score min

Z-score max

Z-score mean

Z-score s.d.

SNP adjusting for

P value after SNP adjustment

16p11.2

QPRT

1.01 × 10−7

17/8

− 2.73

3.04

− 0.59

1.63

rs13338946

0.15

16p11.2

RNF40

4.02 × 10−7

24/3

0.05

5.68

4.67

1.48

rs13338946

0.89

16p11.2

PRR14

4.28 × 10−7

2/2

− 5.38

− 0.20

− 2.79

3.66

rs13338946

0.34

16p11.2

C16orf93

8.07 × 10−7

13/5

− 5.74

− 0.34

− 4.59

1.73

rs13338946

0.24

16p11.2

RP11-2C24.5

1.54 × 10−6

5/5

− 5.64

4.43

− 0.58

3.80

rs13338946

0.73

16p11.2

PRSS53

1.71 × 10−6

16/8

− 5.19

3.68

− 1.04

2.71

rs13338946

0.79

16q23.1

RFWD3

7.71 × 10−7

34/7

− 3.41

6.35

2.51

3.26

rs7193541

0.47

17p11.2

TBC1D27

1.95 × 10−13

6/6

− 1.91

4.19

0.51

2.16

rs34562254

0.89

17p11.2

USP32P1

4.88 × 10− 13

3/3

− 7.29

2.80

−1.36

5.27

rs34562254

0.01

17p11.2

PEMT

5.65 × 10−8

14/7

− 1.74

5.43

1.36

1.93

rs34562254

0.01

22q13.1

APOBEC3C

1.10 × 10−18

21/8

− 8.93

0.24

− 4.09

2.21

rs139402

0.13

22q13.1

APOBEC3H

4.28 × 10−15

7/5

− 5.45

7.92

− 0.95

4.38

rs139402

0.76

22q13.1

FAM83F

4.65 × 10−10

11/8

− 4.25

2.56

− 0.48

2.01

rs139402

1.1 × 10−4

22q13.1

APOBEC3D

6.2 × 10−10

29/7

− 8.38

− 0.85

− 4.15

1.56

rs139402

0.04

22q13.1

APOBEC3F

5.15 × 10−9

5/4

− 6.34

6.15

1.09

5.07

rs139402

0.13

22q13.1

APOBEC3G

1.81 × 10−7

43/2

0.36

6.57

4.94

1.17

rs139402

0.17

2p23.3

KIF3C

1.65 × 10−18

6/6

− 9.40

4.35

− 1.19

4.50

rs7577599

1.4 × 10−9

2p23.3

EPT1

8.37 × 10−16

9/9

− 1.76

6.00

1.30

2.72

rs7577599

2.1 × 10−5

2p23.3

CENPO

1.48 × 10−13

12/8

− 6.60

2.22

− 0.05

2.57

rs7577599

6.1 × 10−8

2p23.3

DNMT3A

2.44 × 10−13

8/8

− 2.89

7.96

1.94

3.07

rs7577599

0.01

2p23.3

AC010150.1

2.90 × 10−13

4/4

− 0.88

7.89

1.61

4.20

rs7577599

8.9 × 10−10

2p23.3

PTGES3P2

4.46 × 10−11

7/5

− 4.23

2.03

− 2.46

2.08

rs7577599

1.1 × 10−4

2p23.3

DTNB

1.16 × 10−7

11/10

− 3.88

5.78

0.36

2.38

rs7577599

3.1 × 10−3

2p23.3

DNAJC27

1.74 × 10−7

8/8

− 0.74

4.52

1.95

1.58

rs7577599

0.11

3p22.1

ULK4

9.01 × 10−15

43/6

0.90

8.89

6.60

2.24

rs6599192

0.85

3q26.2

MYNN

7.84 × 10−13

6/6

− 7.91

1.58

− 1.66

3.32

rs10936600

0.17

3q26.2

LRRIQ4

9.63 × 10−9

3/2

− 5.94

− 0.88

− 4.25

2.92

rs10936600

0.03

3q26.2

LRRC34

3.35 × 10−8

21/2

3.97

6.47

5.12

0.66

rs10936600

0.82

3q26.2

ACTRT3

4.28 × 10−7

4/4

− 0.94

5.80

1.56

2.94

rs10936600

0.48

6q21

ATG5

1.55 × 10−12

4/4

0.93

5.89

3.72

2.41

rs9372120

0.07

7p15.3

CDCA7L

9.61 × 10−9

8/8

− 3.11

4.61

1.12

2.42

rs75341503

0.23

7q36.1

CHPF2

2.53 × 10−7

6/6

− 2.01

2.13

0.40

1.49

rs7781265

0.06

  1. Excludes associations found in the HLA region. s.d., standard deviation. Detailed are the S-MultiXcan P values for association between gene expression MM, and the corresponding Z-scores quantifying this relationship (e.g. a positive score indicates increased gene expression increases risk). N and Nindep indicate the total number of single-tissue results used for S-MultiXcan analysis and the number of independent components after singular value decomposition, respectively
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Human Genomics

ISSN: 1479-7364