Fig. 3
Copy number alteration 8q24.3 is the main inductor for Hsf1 expression. a Distribution per chromosome of the positively and negatively correlated expressed genes with HSF1 expression (see Fig. 1c) in all histopathological cancer types. p values were calculated using the hypergeometric test. b Venn diagram showing the proportion of the co-expressed genes with HSF1 presents in the 8q24.3 cytoband. p values were calculated with the hypergeometric test. Abbreviations: n, number of genes. c Linear correlation between HSF1 CNA and the average CNA of 8q24.3 genes for all samples. Abbreviations: N, number of individual; RMSE, root-mean-square error; R2 = determination coefficient. d Categorical treemap of the average CNA of genes present in 8q24.3 for all tumor samples (left panel). Numbers displayed for the treemap represent the average copy number alteration for all genes located in 8q24.3. “0” is the number of extra copy relative to the diploid reference. The left panel displays for each category presented in the right panel the associated variance of the average CNA. Intermediate colors not presented in the color legend represent the average copy number alteration for all genes with non-null variance. e Categorical treemap of the CNA variance for all genes located in 8q24.3 for all individuals. 92.9% of the tumor patients display a homogenous 8q24.3 region independently of the copy number alteration. f Categorical treemap summarizing categories of tumor displaying different 8q24.3 CNA. Heterogeneous CNA of genes within the 8q24.3 region have been categorized as heterogeneous. g Treemap of all tumor samples grouped per quintile of HSF1 expression strength displaying the proportion of different 8q24.3 CNA category. Tumor samples having heterogeneous 8q24.3 copy number are excluded. Abbreviations: N, number of individual per categories