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Table 2 Immune/interferon response genes associated with CES-D depression scores ≥ 16 in logistic regression models adjusted for HIV status and tobacco smoking

From: Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms

GeneDescriptionContinuous expression (per glog2 increase)Categorical expression (highest vs. middle and lowest tertiles)
OR (95% CI)pOR (95% CI)p
IFI35Interferon induced protein 352.49 (1.06, 6.29)0.0411.93 (0.78, 4.76)0.15
IFNAR1Interferon alpha and beta receptor subunit 13.07 (1.00, 10.45)0.0592.72 (1.09, 6.85)0.032
OAS12'-5'-oligoadenylate synthetase 11.97 (1.07, 3.85)0.0352.35 (0.95, 5.87)0.064
OAS22'-5'-oligoadenylate synthetase 22.37 (1.07, 5.68)0.0392.67 (1.07, 6.72)0.035
PGM2Phosphoglucomutase 29.35 (1.63, 64.55)0.0163.50 (1.42, 8.89)0.0070
PSMD1Proteasome 26S subunit, non-ATPase 116.80 (2.33, 157.17)0.00814.14 (1.66, 10.71)0.0026
STAT1Signal transducer and activator of transcription 11.99 (0.92, 4.46)0.0832.41 (0.97, 6.01)0.056
SP100SP100 nuclear antigen6.77 (0.96, 52.49)0.0581.96 (0.76, 5.00)0.16
  1. Separate multivariable logistic regression models were fit for each indicated gene with CES-D depression scores ≥ 16 (n = 30) vs. < 16 as outcome variable for n = 115 samples with available CES-D data. All models were adjusted by a categorical variable for HIV and smoking status. CES-D, Centers for Epidemiologic Studies Depression; CI, confidence interval; OR, odds ratio