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Table 2 Immune/interferon response genes associated with CES-D depression scores ≥ 16 in logistic regression models adjusted for HIV status and tobacco smoking

From: Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms

Gene Description Continuous expression (per glog2 increase) Categorical expression (highest vs. middle and lowest tertiles)
OR (95% CI) p OR (95% CI) p
IFI35 Interferon induced protein 35 2.49 (1.06, 6.29) 0.041 1.93 (0.78, 4.76) 0.15
IFNAR1 Interferon alpha and beta receptor subunit 1 3.07 (1.00, 10.45) 0.059 2.72 (1.09, 6.85) 0.032
OAS1 2'-5'-oligoadenylate synthetase 1 1.97 (1.07, 3.85) 0.035 2.35 (0.95, 5.87) 0.064
OAS2 2'-5'-oligoadenylate synthetase 2 2.37 (1.07, 5.68) 0.039 2.67 (1.07, 6.72) 0.035
PGM2 Phosphoglucomutase 2 9.35 (1.63, 64.55) 0.016 3.50 (1.42, 8.89) 0.0070
PSMD1 Proteasome 26S subunit, non-ATPase 1 16.80 (2.33, 157.17) 0.0081 4.14 (1.66, 10.71) 0.0026
STAT1 Signal transducer and activator of transcription 1 1.99 (0.92, 4.46) 0.083 2.41 (0.97, 6.01) 0.056
SP100 SP100 nuclear antigen 6.77 (0.96, 52.49) 0.058 1.96 (0.76, 5.00) 0.16
  1. Separate multivariable logistic regression models were fit for each indicated gene with CES-D depression scores ≥ 16 (n = 30) vs. < 16 as outcome variable for n = 115 samples with available CES-D data. All models were adjusted by a categorical variable for HIV and smoking status. CES-D, Centers for Epidemiologic Studies Depression; CI, confidence interval; OR, odds ratio