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Fig. 5 | Human Genomics

Fig. 5

From: Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals

Fig. 5

The transcriptional response of genetically female (HepaRG) and male (HepG2) hepatocytes to 1 μM GEN for 6 h. a A Venn diagram of similar and unique significantly altered genes (p < 0.05) in HepaRG and HepG2 cells. Top 10 induced or repressed genes in HepaRG (b) and HepG2 (c) cells. Top 10 predicted canonical signaling pathways and molecular and cellular functions by GEN in HepaRG (d) and HepG2 (e) cells. Induced or repressed molecules of the “Estrogen Receptor Signaling” pathway by GEN in HepaRG (f) and HepG2 (g) cells

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