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Fig. 5 | Human Genomics

Fig. 5

From: Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Fig. 5

Comparison of the liver and plasma metabolomic data for wild type and Aldh1l2 KO male mice. a Summary of metabolome analysis. b Venn diagram showing metabolites changed in liver and plasma upon ALDH1L2 loss. c, d OPLS-DA of metabolomic data for the plasma and liver of wild type and KO mice. e Schematic depicting the fate of fatty acids: in the case of β-oxidation impairment (linked to CoA deficiency in Aldh1l2 KO mice) fatty acids are conjugated with carnitine and glycine and directed to the blood or converted to triglycerides and deposited in the liver. f, g Acylcarnitines and acylglycines are elevated in plasma of Aldh1l2 KO mice

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Human Genomics

ISSN: 1479-7364