The haplotypes of various TNF related genes associated with scleritis in Chinese Han

Table 2 Association of two SNPs in TNFAIP3 with scleritis diseases

Genotype/allele	Cases		Controls		P value	Pc value	OR (95% CI)
Genotype/allele	n	%	n	%	P value	Pc value	OR (95% CI)
rs9494885	N = 555		N = 739
TT	474	0.854	659	0.892	0.042	NS	0.710 (0.510–0.989)
TC	79	0.142	78	0.105	0.045	NS	1.406 (1.007–1.965)
CC	2	0.004	2	0.003	0.773	NS	1.333 (0.187–9.491)
T	1027	0.925	1396	0.945	0.047	NS	0.727 (0.530–0.997)
C	83	0.075	82	0.055	0.047	NS	1.376 (1.003–1.886)
rs2230926	N = 553		N = 724
GG	2	0.004	2	0.003	0.787	NS	1.310 (0.184–9.331)
GT	56	0.101	50	0.069	0.039	NS	1.519 (1.020–2.263)
TT	495	0.895	672	0.928	0.037	NS	0.660 (0.446–0.977)
G	60	0.054	54	0.037	0.040	NS	1.481 (1.016–2.157)
T	1046	0.946	1394	0.963	0.040	NS	0.675 (0.464–0.984)

Pc value P value with Bonferroni correction, CI confidence interval, OR odds ratio, TNFAIP3 tumor necrosis factor alpha-induced protein 3. Pc value < 0.05 was regarded to have statistical significance

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