Table 1 Marginal effects of 8 super variants in the complete dataset

Dominant

Gene

OR

95% CI of OR

p value

HR

95% CI of HR

p value

chr6_148

STXBP5/STXBP5-AS1

2.909

[1.938, 4.365]

1.4 × 10^-7

2.048

[1.435, 2.921]

7.7 × 10^-5

chr8_99

CPQ

1.923

[1.419, 2.605]

1.6 × 10^-5

1.502

[1.119, 2.015]

6.7 × 10^-3

chr16_4

CLUAP1

2.725

[1.744, 4.259]

7.0 × 10^-6

2.123

[1.433, 3.143]

1.7 × 10^-4

chr17_26

WSB1

4.237

[2.472, 7.263]

8.4 × 10^-8

2.956

[1.949, 4.482]

3.4 × 10^-7

Recessive

Gene

OR

95% CI of OR

p value

HR

95% CI of HR

p value

ch2_197

DNAH7/SLC39A10

2.553

[1.801, 3.616]

7.3 × 10^-8

1.625

[1.170, 2.257]

3.8 × 10^-3

chr2_221

DES/SPEG

2.739

[1.893, 3.963]

4.9 × 10^-8

2.614

[1.894, 3.609]

5.2 × 10^-9

chr7_23

TOMM7

2.411

[1.774, 3.276]

9.5 × 10^-9

1.943

[1.451, 2.603]

8.1 × 10^-6

chr10_57

PCDH15

2.521

[1.736, 3.662]

7.1 × 10^-7

1.813

[1.283, 2.561]

7.4 × 10^-4