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Table 1 Associations of normalized MT-CN with disposition index and Matsuda ISI in METSIM. Testing was done by linear regression using disposition index and Matsuda ISI, respectively, as the dependent variable. P* columns represent the P value from linear regression with additional adjustment for fat mass. Follow-up measurements were taken at a later time point.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

  Baseline Follow-up
Number Beta SE P P* Number Beta SE P P*
Disposition index
All subjects 2975 0.094 0.004 3.0 x 10-7 0.0004 2492 0.062 0.004 0.002 0.068
Excludes diabetic subjects at baseline 2842 0.091 0.003 1.3 x 10-6 0.0007 2452 0.067 0.004 0.0009 0.041
Excludes diabetic subjects at baseline and during follow-up 2453 0.069 0.003 0.0007 0.023 2449 0.067 0.004 0.0009 0.042
Matsuda ISI
All subjects 2975 0.192 0.005 4.3 x 10-26 7.3 x 10-17 2492 0.157 0.006 3.7 x 10-15 8.7 x 10-10
Excludes diabetic subjects at baseline 2842 0.191 0.005 1.0 x 10-24 2.4 x 10-16 2452 0.161 0.006 1.3 x 10-15 3.0 x 10-10
Excludes diabetic subjects at baseline and during follow-up 2453 0.173 0.005 7.2 x 10-18 5.3 x 10-12 2449 0.16 0.006 1.7 x 10-15 3.8 x 10-10