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Table 1 Associations of normalized MT-CN with disposition index and Matsuda ISI in METSIM. Testing was done by linear regression using disposition index and Matsuda ISI, respectively, as the dependent variable. P* columns represent the P value from linear regression with additional adjustment for fat mass. Follow-up measurements were taken at a later time point.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

 

Baseline

Follow-up

Number

Beta

SE

P

P*

Number

Beta

SE

P

P*

Disposition index

 All subjects

2975

0.094

0.004

3.0 x 10-7

0.0004

2492

0.062

0.004

0.002

0.068

 Excludes diabetic subjects at baseline

2842

0.091

0.003

1.3 x 10-6

0.0007

2452

0.067

0.004

0.0009

0.041

 Excludes diabetic subjects at baseline and during follow-up

2453

0.069

0.003

0.0007

0.023

2449

0.067

0.004

0.0009

0.042

Matsuda ISI

 All subjects

2975

0.192

0.005

4.3 x 10-26

7.3 x 10-17

2492

0.157

0.006

3.7 x 10-15

8.7 x 10-10

 Excludes diabetic subjects at baseline

2842

0.191

0.005

1.0 x 10-24

2.4 x 10-16

2452

0.161

0.006

1.3 x 10-15

3.0 x 10-10

 Excludes diabetic subjects at baseline and during follow-up

2453

0.173

0.005

7.2 x 10-18

5.3 x 10-12

2449

0.16

0.006

1.7 x 10-15

3.8 x 10-10