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Table 3 GREML and GREML-LDMS heritability estimates for normalized MT-CN and low-density lipoprotein (LDL) in METSIM. GREML-LDMS heritability estimates are calculated using PCs 1–10 as fixed-effect covariates. Analyses of imputed array data exclude samples with WGS data.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Trait Genotype source (phenotype source) Number GREML GREML-LDMS
h2 SE h2 SE
Normalized MT-CN WGS
(WGS-measured MT-CN)
3065 0.31 0.07 0.31 0.09
Imputed array (WES-measured MT-CN) 6789 0.11 0.04 0.14 0.05
LDL WGS 3062 0.34 0.08 0.38 0.10
Imputed array 6787 0.25 0.04 0.32 0.05