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Table 1 Parkinson's disease associated risk SNPs from an East Asian meta-genome-wide association study (Foo et al. [20])

From: Evaluation of low-pass genome sequencing in polygenic risk score calculation for Parkinson’s disease

rs ID Chromosome Position Effect allele Featurea Effect allele frequency
gnomAD v3.1 ALL gnomAD v3.1 EAS NARD ALL NARD KOR
rs823118 1 205,723,572 T EUR replicated 45.7% 54.3% 51.4% 52.5%
rs6679073 1 205,756,484 A EAS 22.0% 53.3% 49.7% 51.2%
rs16846351 1 226,846,712 G EAS 1.6% 6.3% 6.0% 6.4%
rs4653767 1 226,916,078 T EUR replicated 72.7% 72.1% 23.8% 22.2%
rs2292056 3 182,735,211 T EAS 77.9% 41.5% 59.9% 63.1%
rs12637471 3 182,762,437 G EUR replicated 75.3% 42.0% 59.9% 62.9%
rs34311866 4 951,947 C EUR replicated 14.2% 13.8% 17.7% 16.9%
rs11724635 4 15,737,101 A EUR replicated 43.5% 37.5% 36.9% 34.3%
rs3816248 4 77,101,068 T EAS 86.6% 66.1% 32.5% 33.4%
rs356182 4 90,626,111 G EUR replicated 35.2% 66.2% 31.6% 29.1%
rs6826785 4 90,682,474 C EAS 21.7% 54.8% 54.7% 55.5%
rs246814 5 75,599,208 T EAS 9.6% 9.1% NA NA
rs1887316 6 112,151,452 G EAS 81.1% 87.9% 12.4% 14.2%
rs997368 6 112,243,291 A EUR replicated 65.5% 64.2% 39.3% 39.6%
rs9638616 7 70,750,493 T EAS 37.9% 49.2% 55.0% 55.1%
rs12278023 11 83,510,117 T EAS 55.1% 50.2% 47.7% 48.6%
rs3793947 11 83,544,472 G EUR replicated 57.4% 53.4% 46.3% 47.0%
rs141336855 12 40,387,749 T EAS 0.1% 2.6% 2.4% 2.4%
rs12456492 18 40,673,380 G EUR replicated 32.8% 38.0% 42.7% 40.9%
rs4130047 18 40,678,235 C EAS 32.2% 37.8% 42.6% 40.7%
  1. aFeature: EAS represents significant SNPs from this GWAS (P < 5.00 × 10–8); EUR replicated represents replicated SNPs in this GWAS (P < 1.00 × 10–5)