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Fig. 1 | Human Genomics

Fig. 1

From: Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells

Fig. 1

Constrained cluster analysis. A Clustering of single-cell RNA seq data from three distinct post-mortem neurotypical human brain regions (coloured green)—anterior cingulate cortex (ACC), middle temporal gyrus (MTG) and primary visual cortex (VISp). Clustering of single-cell transcriptome data is shown for each region defined by the tSNE plot (tSNE1 x-axis and tSNE2 y-axis), and each colour represents a unique cluster. B Enrichment of critical exon genes for each cluster is shown. Enrichment was conducted between differentially expressed genes of a cluster (with unique colour horizontal line) and their overlap with pre-computed critical exon matrix from prenatal (PN), early childhood (EC) and adult (AD) brain RNA seq data. Y-axis shows the significance (-log(p) and x-axis shows odds ratio (OR) of critical exon gene enrichment for each cluster and compared between the developmental stages. C Enrichment of high pLI (> 0.90) genes across all clusters shown in radial plots. Enrichment of each brain region shown in unique colours and the width and height of the graph represents OR and the colour intensity represents –log(p) of the enrichment value

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Human Genomics

ISSN: 1479-7364