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Fig. 5 | Human Genomics

Fig. 5

From: Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells

Fig. 5

Replication of association between cluster genes and cell type in other validation datasets. A Fold change (y axis) of top cluster genes intersected with LOF genes, non-neuronal genes, known marker genes and housekeeping genes across ACC, MTG and VISp brain regions. B Cluster-cell type associations (plotted by mean expression (grey) for the 10 most fold change (blue) genes on y axis in 3 significant clusters across oligodendrocytes, astrocytes, OPC, microglia, neurons among ACC, MTG and VISp brain regions. C Mean expression (grey) of 10 most fold change (yellow) genes on y axis in 3 significant clusters across oligodendrocytes, astrocytes, OPC, microglia, neurons among ACC, MTG and VISp brain regions. D Enrichment of ASD LOF variant genes across cell types of cerebrum and cerebellum regions of fetal brain. The y axis here represents cell types, x axis odds ratio, the size of the circle by overlap gene size and the gradient represent p value

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Human Genomics

ISSN: 1479-7364