Integrative analysis of multi-omics data to detect the underlying molecular mechanisms for obesity in vivo in humans

Table 2 Gene modules identified by MEGENA

ID	Module size	Module parent	Module hub	Module scale	Module p value
c1_2	95	c1_1	()	S3	< 1e−5
c1_3	29	c1_1	UGGT1 (13)	NA	< 1e−5
c1_4	90	c1_1	MPEG1 (21), IQGAP1 (19)	S3	< 1e−5
c1_5	30	c1_2	LUZP6*(13), ANO6 (12)	S3	< 1e−5
c1_6	35	c1_2	PTGS1 (15)	S3	< 1e−5
c1_8	12	c1_2	()	S3	< 1e−5
c1_10	10	c1_3	()	NA	< 1e−5
c1_12	64	c1_4	MPEG1 (21), IQGAP1 (19)	S2	< 1e−5
c1_13	26	c1_4	()	S2	0.04
c1_16	12	c1_5	ANO6(9)	S2	< 1e−5
c1_18	18	c1_6	PTGS1 (11), CLU (9)	NA	< 1e−5
c1_23	52	c1_12	MPEG1 (21), IQGAP1 (17)	NA	< 1e−5
c1_24	12	c1_12	()	S1	< 1e−5
c1_25	12	c1_13	PLCB2*(9)	S1	< 1e−5
c1_26	14	c1_13	()	S1	< 1e−5
c1_29	25	c1_23	MPEG1 (18)	NA	< 1e−5
c1_34	21	c1_29	MPEG1 (18)	S1	< 1e−5

Module size means the number of genes in each module, module parent means the beginning from connected components of the initial networks, module hub means the hub gene in this module, module scale demonstrates that three scales groups (S1, S2 and S3) were identified that had similar interaction patterns and shared highly connected hubs across different scales. The numbers inside the parenthesis in column 'module hub' mean the number of genes directed connected to the hub gene

ISSN: 1479-7364