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Table 1 Comparison laboratory parameters between dead and improved patients infected with COVID-19

From: On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity

Variables

dead patients (n = 495)

Improved patients (n = 497)

P-value

Mean age ± SD

62.6 ± 11.9

51.1 ± 11.8

0.515

Gender (male/female)

259/236 (52.3/47.7%)

270/227 (54.3/45.7%)

0.527

ALT, IU/L (mean ± SD) (Reference range: 5–40)

32.6 ± 19.5

31.2 ± 20.1

0.144

AST, IU/L (mean ± SD) (Reference range: 5–40)

33.9 ± 18.2

30.8 ± 17.4

0.064

ALP, IU/L (mean ± SD) (Reference range: up to 306)

178.7 ± 81.4

163.9 ± 79.4

0.073

Cholesterol, mg/dL (mean ± SD) (Reference range: 50–200)

116.1 ± 46.4

128.5 ± 51.2

 < 0.001*

TG, mg/dL (mean ± SD) (Reference range: 60–165)

128.7 ± 59.8

137.1 ± 61.2

0.025*

LDL, mg/dL (mean ± SD) (Reference range: up to 150)

62.3 ± 29.7

95.4 ± 48.2

 < 0.001*

HDL, mg/dL (mean ± SD) (Reference range: > 40)

32.1 ± 11.9

34.4 ± 12.5

0.813

WBC, 109/L (mean ± SD) (Reference range: 4000–10,000)

7553.0 ± 2680.1

7773.5 ± 2865.9

0.245

CRP, mg/L (mean ± SD) (Reference range: < 10 mg/L Negative)

70.1 ± 21.4

51.9 ± 19.2

 < 0.001*

ESR, mm/1st h (mean ± SD) (Reference range: 0–15)

56.3 ± 15.7

45.9 ± 15.1

 < 0.001*

FBS, mg/dL (mean ± SD) (Reference range: 70–100)

106.8 ± 41.5

107.2 ± 42.1

0.806

Platelets × 1000/cumm (mean ± SD) (Reference range: 140,000–400,000)

185 ± 77

183 ± 68

0.577

T3, ng/dL (mean ± SD) (Reference range: 2.3–4.2)

3.5 ± 1.6

2.7 ± 1.3

0.066

T4, mcg/dL (mean ± SD) (Reference range: 5.6–13.7)

9.1 ± 6.8

8.4 ± 6.3

0.128

TSH, mu/L (mean ± SD) (Reference range: 0.4–4.5)

3.4 ± 2.1

3.1 ± 1.7

0.808

Hemoglobin, g/dL (mean ± SD) (Reference range: 12–18)

14.2 ± 2.2

12.8 ± 1.5

0.378

BUN, mg/dL (mean ± SD) (Reference range: 15–45)

39.2 ± 6.2

38.1 ± 7.1

0.527

Creatinine, mg/dL (mean ± SD) (Reference range: 0.6–1.4)

1.5 ± 0.7

0.9 ± 0.3

0.107

25-hydroxy vitamin D, ng/mL (mean ± SD) (Sufficiency: 21–150)

19.4 ± 9.2

40.2 ± 12.8

 < 0.001*

Real-time PCR Ct values

12.4 ± 6.2

29.1 ± 9.3

0.010*

TRIM22 rs1063303

CC genotype

69 (13.9%)

197 (39.6%)

 < 0.001*

GC genotype

258 (52.2%)

224 (45.1%)

 

GG genotype

168 (33.9%)

76 (15.3%)

 

TRIM22 rs7935564

AA genotype

89 (18.0%)

261 (52.5%)

 < 0.001*

AG genotype

159 (32.1%)

186 (37.4%)

 

GG genotype

247 (49.9%)

50 (10.1%)

 

TRIM22 rs7113258

AA genotype

109 (22.0%)

294 (59.2%)

 < 0.001*

AT genotype

159 (32.1%)

151 (30.4%)

 

TT genotype

227 (45.9%)

52 (10.4%)

 
  1. ALT alanine aminotransferase; AST aspartate aminotransferase; ALP alkaline phosphatase; TG triglyceride; LDL low-density lipoprotein; HDL high-density lipoprotein; WBC white blood cells; CRP C-reactive protein; ESR erythrocyte sedimentation rate; FBS fasting blood glucose; T3 triiodothyronine; T4 thyroxine; TSH Thyroid-stimulating hormone; BUN Blood urea nitrogen; Ct cycle threshold; SD standard deviation
  2. *Statistically significant (< 0.05)
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Human Genomics

ISSN: 1479-7364