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Fig. 2 | Human Genomics

Fig. 2

From: Alternative transcription start sites contribute to acute-stress-induced transcriptome response in human skeletal muscle

Fig. 2

Contribution of alternative TSSs to acute-stress-induced transcriptome response and their functional role. A. Number of differentially expressed genes (DEGs) relative to pre-exercise and their overlap at different time points after acute exercise. Up- and down-regulated genes are shown in red and blue, respectively; the number of time-specific DEGs is underlined. B. Principal component analysis shows the consistency of gene responses in different volunteers at different time points during the first hours after acute exercise. C. Number of DEGs having one (532 genes) or several (733 and 146 genes) TSSs and showing differential TSSs usage (146 genes). Another set of genes (111 genes) shows differential TSSs usage without altering the overall expression of each gene. D. Examples of different TSS regulation patterns. E. Distribution of TSSs per gene and a potential functional role of the alternative TSSs

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Human Genomics

ISSN: 1479-7364