Table 2 Differential methylation patterns by gene location

F-box only protein 16 (FBXO16)

Promotes phosphorylation-dependent ubiquination and degradation, involved in controlling amount of protein in eukaryotes

Degradation of beta-catenin leads to decreased cell adherent protein expression, leading to disruption of cardiac electrical and mechanical communication between myocytes

Pleckstrin and Sec7 domain containing 3 (PSD3)

Codes protein, involved in endocytosis, implicated in tumor suppression

Increases signal transduction targeting proteins to subcellular compartments to respond to viral infection

Ribonucleic acid export 1 (RAE1)

Nucleocytoplasmic transport, mitotic checkpoint regulator

This tumor suppressor gene may be important for cell division in immune cells

NIPA like domain containing 2 (NIPAL2)

Autosomal recessive gene associated with congenital ichthyosis

Involved in transport of glucose and other sugars, likely in response to increased metabolic demands of infection

SH3 and multiple ankyrin repeat domains 2 (SHANK2)

Codes postsynaptic proteins at excitatory synapses, disruption may predispose to autism or developmental delay

May play a role in SARS-CoV-2 induced altered mental status

Phosphoglucomutase 1 (PGM1)

Codes isozyme of phosphoglucomutase (PGM), mutations cause glycogen storage disease type 14, highly polymorphic, mutations causes glycogen storage disease

Associated with breakdown and synthesis of glucose, upregulated during acute infection due to metabolic demands