Integrated proteomic and metabolomic modules identified as biomarkers of mortality in the Atherosclerosis Risk in Communities study and the African American Study of Kidney Disease and Hypertension

Table 2 Mortality associations of the four modules associated in both the Atherosclerosis Risk in Communities study (ARIC) general population cohort and the African American Study of Kidney Disease and Hypertension (AASK) cohort of patients with chronic kidney disease

Biomarker	ARIC		AASK		Module components
Module (PC)	HR (95% CI)	P-value	HR (95% CI)	P-value	Proteins \| Metabolites bold: cor_ARIC(module PC) > = 0 non-bold: cor_ARIC(module PC) < 0
67 (pc1)	1.39 [1.28,1.50]	1.92E−16	1.49 [1.23,1.82]	6.60E−05	ADAM 17, Apo A-I, ATL2, MGP, SPLC2, TSP2 \| chiro-inositol, N-methylproline, ribitol, 3-methylhistidine
30 (pc1)	0.74 [0.68,0.80]	7.93E−15	0.61 [0.50,0.76]	4.25E−06	kallikrein 10, kallikrein 13, N-terminal pro-BNP, SPB13, SVEP1, TPSB2 \| Beta-citrylglutamate
98 (pc2)	1.26 [1.17,1.36]	3.05E−9	1.49 [1.22,1.82]	1.14E−-4	ANGL3, ENPP5, GDF-11/8, SIA10 \| guanidinoacetate, kynurete, xanthurenate
42 (pc2)	1.2 [1.11,1.29]	1.59E−06	1.46 [1.20,1.78]	1.40E−04	ARY1, MICB, ITI heavy chain H1, NRP1, MOTI, NRP1\| anthranilate, cysteine s-sulfate, N-formylanthranilic acid, phenylacetate, phenylacetylcarnitine, phenylacetylglutamate

ISSN: 1479-7364