Fig. 1

Overview of the analytical pipeline conceived and developed in this study. A Integration of transcriptomics public datasets through a gene expression integrated analysis. Differentially expressed genes reported in all of the included DNA microarray platforms were used in order to build gene co-expression network models of lesional and non-lesional skin from psoriasis patients. B Network analyses performed on the inferred networks. In particular, the analyses carried out in this study include a differential centrality analysis between the lesional and non-lesional skin network models, the identification of bridge genes in the lesional network, the functional annotation of co-expression modules of the lesional network, the enrichment of immune cell-specific genes and the evaluation of the druggability of the lesional skin network. Panel C shows the psoriasis disease map inferred in the present study