Fig. 3

Regional plots for significant genotype–metabotype associations. The genomic coordinates (x-axis) are based on GRCh38. The variant with the strongest p value is highlighted with its coordinate, reference, and variant alleles. The boxplot (shown next to the regional plot) shows the distribution of normalized feature intensity by genotype for the strongest variant. Feature annotation is from xMSannotator with high and medium confidence or from HMDB with exact mass at 5-ppm tolerance (level 5 annotation according to Schymanski et al.) A significant loci for Ne,Ne dimethyllysine (m/z 175.1442, RT 104.5) around PYROXD2 on chromosome 10. B loci for Menthol propylene glycol carbonate (m/z 300.2167, RT 37.1) on ACADL on chromosome 2. C, D shows the two separate loci on chromosome 7 for Tridecanol (m/z 283.2741, RT 27.6), located in two genes CALN1 and VWDE, respectively