Fig. 2

Perturbations of the expression of TRIM protein family in cancer. A Landscape of differential expression of TRIM proteins family between normal and tumor samples across cancer types. Heatmap on the left panel showing the log2(fold-changes) of TRIM genes across cancer types, where '*' indicates significant difference. Bar plots on the right panel showing the number of cancers that the corresponding TRIM genes perturbed. Red represents up-regulated expression in cancer, and blue represents decreased expression. B and C Box plots showing the expression levels of TRIM28 (B) and TRIM58 (C) between normal and tumor samples across 18 cancer types. The point represents the median value of expression, and sides of the line represent the upper and lower quartiles of that. Wilcoxon rank sum test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. D Boxplots showing the SCC distributions of TRIM genes within and between different sub-classes. Red represents Spearman correlation coefficient between the same sub-class, and blue represents that between different sub-classes. Wilcoxon rank sum test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. E Circos plot showing the co-expression between TRIM genes. Gene pairs with p value < 0.05 and SCC > 0.75 was plotted. One line indicates strong correlation in one cancer, and multiple lines between two genes indicate strong correlation in multiple cancers