Fig. 3

Functional pathways of TRIM protein family across cancer types. A Gene set enrichment analysis (GSEA) of TRIM genes in various cancers. Heat map showing the normalized enrichment scores (NES) and size of the dots corresponding to the − log10(adjusted p values). Red indicates active pathway, while blue indicates inhibitory pathway. The black border demonstrates significant results. Bar plots on the right panel showing the number of cancers that the corresponding pathway enriched (red) or depleted (blue). B and C The enrichment score (ES) distribution for the genes positively or negatively co-expressed with TRIMs scores in EMT pathway (B) and interferon alpha response pathway (C). Each line is for one cancer and lines are colored by cancer types