Fig. 5

Clinical associations of TRIMs score across cancer types. A The distributions of TRIMs score across cancer types. Dot and lines are colored by cancer types. Within each cancer, the scattered dots represented TRIMs score values. B Boxplots showing the distributions of TRIMs scores between normal (blue) and tumor (red) samples. The point represents the median value of TRIMs score in each cancer, and sides of the line represent the 25th and 75th quartiles of that. The statistical difference of two group was compared through the Wilcoxon rank sum test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. C Area under the ROC curves (AUCs) for classifiers based on TRIMs scores in TCGA cohort. Legends show the basic information of each cancer. Lines are colored by 14 cancer types with 15 or more normal samples. 'h(m–n)' indicates the HR values and 95%CI. D The distribution of hazard ratios (HR) based on TRIMs scores across different cancer types. The point represents the HR value, and sides of the line represent 95%CI. Red dots and lines indicate significant result. E–G Kaplan–Meier survival plot of patients grouped by high versus low TRIMs scores. The group with low TRIMs scores (blue) has poorest survival, whereas the high TRIMs score group (red) is associated with better outcomes (log-rank test p value < 0.05)