Fig. 6

Clinical therapeutic response associated with TRIMs in cancer. A The proportions of patients for therapeutic response between TRIMs scores high and low groups in TCGA cohorts. Patients were classified into progressive disease (PD), stable disease (SD), partial response (PR) and complete response (CR) based on drug treatment responses. Fisher’s exact test was used to compare statistical difference of two group. B Boxplots showing the distributions of TRIMs scores for patients with different therapeutic response to anti-PD1 immunotherapy. The statistical difference of three response stages was compared through the Wilcoxon rank sum test. Patients with better responses have higher TRIMs scores (p value < 0.05). C Proportions of patients with different therapeutic response to anti-PD1 immunotherapy in TIRMs scores high versus low groups. Fisher’s exact test was used to compare statistical difference of two group (p value = 0.0015). D Kaplan–Meier survival plot of patients grouped by high versus low TRIMs scores in anti-PD1 immunotherapy cohort (GSE78220). The group with low TRIMs scores (blue) has poorest survival, whereas the high TRIMs score group (red) is associated with better outcomes (log-rank test p value = 0.0039). E Boxplots showing the distributions of TRIMs scores for patients with different therapeutic response to anti-CTLA-4 immunotherapy. The statistical difference of three response stages was compared through the Wilcoxon rank sum test (p value = 0.0071). F Proportions of patients with different therapeutic response to anti-CTLA-4 immunotherapy in TIRMs scores high versus low groups (Fisher’s exact test, p value = 0.00075). G Kaplan–Meier survival plot of patients grouped by high versus low TRIMs scores in anti-CTLA-4 immunotherapy cohort. The group with low TRIMs scores (blue) has poorest survival, whereas the high TRIMs score group (red) is associated with better outcomes (log-rank test p value = 0.021). H. Kaplan–Meier survival plot of patients grouped by high versus low TRIMs scores in IMvigor210 cohorts. The group with low TRIMs scores (blue) has poorest survival, whereas the high TRIMs score group (red) is associated with better outcomes (log-rank test p value = 0.024)