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Table 4 Association between miRNAs dynamics and rivaroxaban PK-PD profiles

From: Circulating miR-320a-3p and miR-483-5p level associated with pharmacokinetic–pharmacodynamic profiles of rivaroxaban

Group criteria

Fasted

FC3h-0h

p value

Fed

FC3h-0h

p value

Total

FC3h-0h

p value

15 mg

Grouped by AXA3h

 Case: 3 h vs 0 h

miR-320a↑

3.99

0.0156

–

–

–

miR-320a↑

5.47

0.0085

 

miR-483↑

4.01

0.0156

–

–

–

–

–

–

Grouped by AUC0-t

 Case: 3 h vs 0 h

miR-320a↑

3.86

0.0156

miR-320a↑

7.87

0.0156

miR-320a↑

6.46

0.0001

 

miR-483↑

3.48

0.0313

–

–

–

miR-483↑

3.98

0.0017

  1. ↑ indicates that this miRNA expression in the case group was significantly higher at 3 h than at 0 h
  2. –: None
  3. FC3h-0h fold change between 3 and 0 h