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Fig. 1 | Human Genomics

Fig. 1

From: Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Fig. 1

Social behaviors in Tsc1+/−, Tsc2+/−, and TscD+/− mice. A–C Frequencies of head-dipping (A) and self-grooming (B) and time spent in active interaction behaviors (C) in Tsc1+/−, Tsc2+/−, and TscD+/− mice in the hole board test, self-grooming test, and social interaction test, respectively. D Time spent exploring (social approach) a stranger mouse (S1) and non-social object (O) in the three-chamber test. E Time spent exploring a familiar mouse (S1) and stranger mouse (S2) in the social-novelty preference test. F Time spent exploring a cagemate (C) and stranger mouse (S3) in the social preference test. G Approach avoidance score calculated as the following: (time exploring S3) – (time exploring C). *p < 0.05; **p < 0.01; ***p < 0.001, one-way ANOVA followed by Tukey HSD test (A–C, G) and paired t-test (D–F). Each bar indicates the mean ± SEM

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Human Genomics

ISSN: 1479-7364