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Fig. 2 | Human Genomics

Fig. 2

From: Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging

Fig. 2

Analysis of methylation intensity function by age in Dataset1F. a Plots of MIC (X-axis) and Pearson’s correlation coefficient (Y-axis). Each dot represents a methylation site. b QQ plot of nonlinearity index. The nonlinearity index was defined as \(MIC- \rho ^2\). The null distribution was generated by label permutation. The red line represents y = x. c Pie chart showing the genome-wide methylation sites for age-related association types: NC (non-correlated), LI (linear increase), LD (linear decrease), NL (nonlinear) . d Contribution rate for PC1–PC5. e PC1 and PC2 for 1000 randomly selected sites. The colors represent groups detected by clustering. f Representative functions for the identified NL groups (X-axis: age, Y-axis: scaled intensity)

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Human Genomics

ISSN: 1479-7364