Fig. 1
From: Computational network analysis of host genetic risk variants of severe COVID-19
Flow diagram of the study overview. (A) The first step: extracting genetic risk factors of severe COVID-19, by parsing articles and extracting risk factors. such as Variants, Genes, proteins, related diseases, pathways, and interactions. (B) The second step: annotating the genetic risk factors of severe COVID-19 to complete the genetic profiles of identified risk variants from public datasets and platforms. (C) The third step: analyzing molecular functions of risk factors of severe COVID-19 using gene ontology and Gene Card platforms. (D) The fourth step: constructing molecular networks and identifying functions and pathways between risk factors and other molecules from public datasets and platforms. (E) The fifth step: mapping constructed networks of severe COVID-19 with other diseases via shared risk variants using GWAS catalog, ClinGen., and other public resources