Table 1 List of the risk variants for severe COVID-19 and their associated diseases and biomarkers
From: Computational network analysis of host genetic risk variants of severe COVID-19
Risk variants | Chrom. | Diseases and biomarkers | Related system |
|---|---|---|---|
rs45574833 | 1 | Atypical Hemolytic Uremic Syndrome (AHUS) | Renal system |
rs147149459 | 3 | Hyperglycinuria | Neuron system |
rs7626962 | 3 | Heart disease, and Cardiac arrhythmia, Cardiovascular phenotype, and Congenital long QT syndrome | Cardiovascular system |
rs61756766 | 4 | High level of white blood cell count procedure biomarker | Immune and hematopoietic systems |
rs13168774 ,rs35652899, rs8176746, rs150892504 | 5 | Asthma, and Systemic primary carnitine deficiency (CDSP) | Respiratory and metabolic systems |
rs1800795 | 7 | Alzheimer’s disease, Rheumatoid arthritis, KAPOSI Sarcoma, Diabetes mellitus type 1 and 2 | Neuron and metabolic systems |
rs495828 | 9 | Three-vessel disease (3VD) | Cardiovascular system |
rs505922 | 9 | Diabetes mellitus Non-insulin-dependent, and high level of red blood cell count | Metabolic system |
rs12683493 | 9 | Mean Corpuscular Hemoglobin Concentration (MCHC) | Hematopoietic system |
rs657152 | 9 | Venous thromboembolism, and low level of thyroid stimulating hormone | Hematopoietic system |
rs6127099 | 9 | Von Willebrand disease (VWD) | Hematopoietic system |
rs12252 | 11 | Severe influenza, hypercholesterolemia, dengue fever, pneumonia, hepatoma, HIV-1 infection | Immune system |
rs34481144, rs6598045 | 11 | Severe influenza | Immune system |
rs143359233 | 11 | Suntan | Integumentary systems |
rs4883215 | 12 | Alzheimer’s disease | Neuron system |
rs669 | 12 | Alzheimer’s disease, and Alpha-2-Macroglobulin polymorphism | Neuron system |
rs4767027 | 12 | Related to level of blood protein biomarker | Hematopoietic system |
rs8039305, rs769208985 | 15 | Hypertension | Circulatory systems |
rs72711165 | 17 | Ichthyosis and Lamellar ichthyosis | Integumentary systems |
rs4343 | 17 | Alzheimer’s disease, high serum albumin level, Myocardial infarction, and renal tubular dysgenesis of genetic origin | Neuron and metabolic systems |
rs4341 | 17 | Diabetes and hypertension, renal tubular dysgenesis of genetic origin | Metabolic and circulatory systems |
rs429358 | 19 | Alzheimer disease, hyperlipoproteinemia | Neuron system |
rs1405655 | 19 | Diabetes mellitus non-insulin-dependent, Inflammatory bowel diseases, and Tuberculosis (TB) | Immune and metabolic systems |
rs2109069 | 19 | Idiopathic pulmonary fibrosis | Respiratory system |
rs12610495 | 19 | Lung Diseases Interstitial | Respiratory system |
rs74956615 | 19 | Rheumatoid arthritis, Cholangitis sclerosing, Ulcerative colitis, Crohn disease, Psoriasis, and Ankylosing spondylitis | Metabolic and integumentary systems |
rs138763430 | 20 | Glomerular Filtration Rate, Vitamin D3 , Parathyroid hormone biomarkers | Hematopoietic and metabolic systems |
rs2070788 | 21 | Cardiac arrhythmia, Atrial fibrillation, Long QT syndrome, Cardiovascular phenotype, Jervell and Lange-Nielsen syndrome 2 | Cardiovascular system |
rs114363287 | 21 | Severe influenza due to influenza A virus subtype H7N9 | Immune system |
rs11702475 | 21 | Prostate carcinoma | Reproductive system |
rs11385942 | 22 | Immunodeficiency | Immune system |
rs200553089, rs2042915990 | X | Immunodeficiency | Immune system |
rs2074192 | X | Cardiovascular diseases, Essential hypertension | Cardiovascular and circulatory systems |
rs2285666 | X | Diabetes mellitus non-insulin-dependent, Hypertensive disease, Dyslipidemias, Orthostatic hypertension | Metabolic and circulatory systems |
rs2106809 | X | Essential Hypertension | Circulatory systems |