Table 2 Main host biological processes associated with the 56 risk proteins that contribute to the development of severe COVID-19
From: Computational network analysis of host genetic risk variants of severe COVID-19
Number of risk protein | High level GO biological process category | Risk protein list |
|---|---|---|
24 | Immune system process | CFH, OAS1, TYK2, ITGA4, COLEC11, C4BPA, C3, APOE, NR1H2, IL6, FURIN, IFITM3, MX1, IFNAR2, ACE, TNFRSF13C, GYG1, CXCR6, A2M, CD55, TLR7, NOTCH4, HLA-G, MAPT |
22 | Response to stress | CFH, OAS1, BRF2, TYK2, F3, COLEC11, C4BPA, C3, APOE, ACE2, NR1H2, IL6, FURIN, IFITM3, MX1, IFNAR2, CXCR6, A2M, CD55, TLR7, HLA-G, MAPT |
22 | Response to external stimulus | CFH, CYP24A1, OAS1, TYK2, ITGA4, F3, COLEC11, C4BPA, C3, APOE, ACE2, NR1H2, IL6, FURIN, IFITM3, MX1, IFNAR2, CXCR6, A2M, CD55, TLR7, HLA-G |
21 | Immune response | CFH, OAS1, TYK2, ITGA4, COLEC11, C4BPA, C3, APOE, NR1H2, IL6, FURIN, IFITM3, MX1, IFNAR2, TNFRSF13C, GYG1, CXCR6, A2M, CD55, TLR7, HLA-G |
21 | Regulation of response to stimulus | CFH, OAS1, PLEKHA4, ITGA4, F3, COLEC11, C4BPA, C3, APOE, ACE2, NR1H2, IL6, FURIN, IFNAR2, A2M, SCN5A, CD55, TLR7, NOTCH4, HLA-G, MAPT |
18 | Regulation of signaling | OAS1, PLEKHA4, F3, C3, APOE, ACE2, NR1H2, IL6, FURIN, IFNAR2, TMEM65, GRM5, A2M, CD55, TLR7, NOTCH4, HLA-G, MAPT |
18 | Biological process involved in interspecies interaction between organisms | CFH, OAS1, TYK2, COLEC11, C4BPA, C3, APOE, ACE2, NR1H2, IL6, IFITM3, MX1, IFNAR2, A2M TMPRSS2, CD55, TLR7, HLA-G |
18 | Regulation of multicellular organismal process | OAS1, F3, C3, APOE, ACE2, NR1H2, IL6, FURIN, ACE, TMEM65, A2M, KCNE1, SCN5A, CD55, TLR7, NOTCH4, HLA-G, MAPT |
16 | Regulation of immune system process | CFH, OAS1, ITGA4, COLEC11, C4BPA, C3, APOE, NR1H2, IL6, FURIN, IFNAR2, TNFRSF13C, A2M, CD55, TLR7, HLA-G |
16 | Response to biotic stimulus | CFH, OAS1, TYK2, COLEC11, C4BPA, C3, APOE, NR1H2, IL6, IFITM3, MX1, IFNAR2, A2M ,CD55, TLR7, HLA-G |
16 | Response to other organism | CFH, OAS1, TYK2, COLEC11, C4BPA, C3, APOE, NR1H2, IL6, IFITM3, MX1, IFNAR2, A2M, CD55, TLR7, HLA-G |
16 | Regulation of biological quality | OAS1, F3, APOE, ACE2, NR1H2, IL6, FURIN, MX1, ACE, GRM5, CXCR6, A2M, KCNE1, SCN5A, CD55, MAPT |
15 | Regulation of localization | ITGA4, F3, AHNAK, C3, APOE, ACE2, NR1H2, IL6, FURIN, ACE, LZTFL1, GRM5, KCNE1, SCN5A, MAPT |
15 | Regulation of molecular function | OAS1, ITGA4, F3, AHNAK, C3, APOE, ACE2, NR1H2, IL6, FURIN, ACE, GRM5, A2M, KCNE1, MAPT |
12 | Cellular localization | ITGA4, C3, APOE, MX1, GYG1, LZTFL1, A2M , KCNE1, SCN5A, CD55, CCHCR1, MAPT |
11 | Anatomical structure morphogenesis | PLEKHA4, ITGA4, F3, C3, APOE, IL6, FURIN, SCN5A, NOTCH4, HLA-G, MAPT |
11 | Macromolecule localization | ITGA4, C3, APOE, NR1H2, IL6, FURIN, ACE, LZTFL1, KCNE1, CCHCR1, MAPT |
10 | Immune effector process | CFH, COLEC11, C4BPA, C3, IL6, ACE, GYG1, A2M, CD55, HLA-G |
10 | System process | APOE, ACE2, NR1H2, ACE, SLC6A20, TMEM65, GRM5, KCNE1, SCN5A, MAPT |
10 | Cell population proliferation | ITGA4, F3, APOE, ACE2, IL6, ACE, TNFRSF13C, SCN5A, CD55, HLA-G |
10 | Cellular component biogenesis | OAS1, BRF2, APOE, ACE2, NR1H2, MX1, ACE, LZTFL1, HLA-G, MAPT |
9 | Regulation of developmental process | PLEKHA4, F3, C3, APOE, NR1H2, IL6, NOTCH4, HLA-G, MAPT |
8 | Leukocyte activation | ITGA4, C3, IL6, TNFRSF13C, GYG1, CD55, HLA-G, MAPT |
7 | Biological adhesion | ITGA4, ACE2, IL6, TNFRSF13C, CD55, NOTCH4, HLA-G |
7 | Catabolic process | CYP24A1, C4BPA, APOE, IL6, FURIN, ACE, MAPT |
7 | Response to endogenous stimulus | ITGA4, APOE, IL6, FURIN, GRM5, KCNE1, MAPT |
7 | Anatomical structure formation involved in morphogenesis | ITGA4, F3, C3, IL6, FURIN, NOTCH4, HLA-G |
6 | Locomotion | ITGA4, F3, APOE, IL6, ACE, CXCR6 |
6 | Activation of immune response | CFH, COLEC11, C4BPA, C3, A2M, CD55 |
6 | Cell adhesion | ITGA4, IL6, TNFRSF13C, CD55, NOTCH4, HLA-G |
6 | Regulation of cell adhesion | ITGA4, IL6, TNFRSF13C, CD55, NOTCH4, HLA-G |
6 | Cell motility | ITGA4, F3, APOE, IL6, ACE, CXCR6 |
6 | Localization of cell | ITGA4, F3, APOE, IL6, ACE, CXCR6 |
5 | Immune system development | ITGA4, IL6, ACE, NOTCH4, HLA-G |
5 | Regulation of locomotion | ITGA4, F3, APOE, IL6, ACE |
5 | Regulation of cellular component biogenesis | APOE, ACE2, NR1H2, ACE, MAPT |
4 | Cell killing | CFH, C3, CD55, HLA-G |
4 | Behavior | APOE, ACE2, GRM5, MAPT |
4 | Maintenance of location | C3, APOE, NR1H2, IL6 |
3 | Reproduction | GOLGA3, C3, ACE |
3 | Reproductive process | GOLGA3, C3, ACE |
3 | Growth | ITGA4, APOE, MAPT |
3 | Production of molecular mediator of immune response | IL6, CD55, HLA-G |
3 | Developmental process involved in reproduction | GOLGA3, C3, ACE |
3 | Cell growth | ITGA4, APOE, MAPT |
3 | Regulation of cell killing | CFH, CD55, HLA-G |
3 | Taxis | F3, IL6, CXCR6 |
3 | Hormone metabolic process | ACE2, FURIN, ACE |
3 | Developmental growth | ITGA4, APOE, MAPT |
3 | Complement-dependent cytotoxicity | CFH, C3, CD55 |
3 | Regulation of hemostasis | F3, APOE, A2M |
2 | Multi-organism process | GOLGA3, ACE |
2 | Locomotory behavior | APOE, GRM5 |
2 | Response to abiotic stimulus | TLR7, MAPT |
2 | Antigen processing and presentation | ACE, HLA-G |
2 | Sexual reproduction | GOLGA3, ACE |
2 | Multicellular organism reproduction | GOLGA3, ACE |
2 | Regulation of growth | APOE, MAPT |
2 | Multi-organism reproductive process | GOLGA3, ACE |
2 | Multicellular organismal reproductive process | GOLGA3, ACE |
2 | Leukocyte migration | ITGA4, IL6 |
2 | Protein activation cascade | F3, A2M |
2 | Regulation of plasma lipoprotein particle levels | APOE, NR1H2 |