Table 3 Summary of the 24 molecular networks constructed using the genetic risk factors for severe COVID-19
From: Computational network analysis of host genetic risk variants of severe COVID-19
Network ID | Risk variants | Risk protein | Host protein | PPI | Main related system | Main related tissues and cells |
|---|---|---|---|---|---|---|
1 | 24 | 16 | 117 | 511 | Immune system | Blood cells |
2 | 7 | 5 | 37 | 75 | Innate immune system | Liver and digestive gland |
3 | 14 | 3 | 15 | 27 | Renin-angiotensin and metabolomic systems | Kidney and viscus tissue |
4 | 1 | 3 | 11 | 27 | Vascular system | Heart and viscus tissue |
5 | 1 | 1 | 11 | 13 | Cardiovascular system | Cardiac muscle fiber and heart tissue |
6 | 1 | 1 | 11 | 55 | Ribosomal protein | Pituitary gland tumor cell |
7 | 4 | 1 | 11 | 33 | Metabolic system | Kidney, heart, liver and adipose |
8 | 1 | 1 | 11 | 19 | Hematopoietic system | Natural killer cell and blood cells |
9 | 1 | 1 | 11 | 28 | Metabolic system | Muscle tissue |
10 | 1 | 1 | 11 | 19 | Immune system | Blood and natural killer cells |
11 | 1 | 1 | 11 | 38 | Central nervous system | Cerebral cortex and brain tissue |
12 | 3 | 1 | 11 | 12 | Endomembrane system | Ovary and testis tissue |
13 | 7 | 1 | 8 | 24 | Metabolic system | Esophagus tissue |
14 | 2 | 2 | 8 | 11 | Metabolic system | Liver |
15 | 1 | 1 | 7 | 14 | Innate Immune system | Low tissue specificity |
16 | 7 | 1 | 6 | 13 | Immune system | Lymphoid tissue in B-cells |
17 | 1 | 1 | 5 | 7 | Urinary and cardiovascular systems | Kidney and heart tissue |
18 | 1 | 1 | 5 | 6 | Cardiovascular system | Heart and skeletal muscle |
19 | 1 | 1 | 3 | 2 | Immune system | Blood cells |
20 | 25 | 1 | 2 | 1 | Immune system | VCaP cell |
21 | 2 | 1 | 2 | 1 | Immune system | Kidney and small intestine |
22 | 1 | 1 | 2 | 1 | Immune and hematopoietic systems | Blood cells |
23 | 1 | 1 | 2 | 1 | Immune and hematopoietic systems | Blood cells |
24 | 1 | 1 | 2 | 1 | Immune and hematopoietic systems | Blood cells |