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Fig. 8 | Human Genomics

Fig. 8

From: Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy

Fig. 8

Validation of functional phenotypes in database and cell lines. (A) Correlations between five RNA methylation regulatory genes and eGFR. (B) Relative expression levels of METTL3, WTAP, YTHDC1, ADAR1, DNMT1 mRNA in immortalized human podocyte cell line (HPC) and mouse podocyte cell line (MPC) by qRT-PCR. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 versus normal glucose (NG) group. (C, D) Immunoblot analysis of RNA methylation regulators protein in high glucose (HG) induced podocytes. (E, F) Immunoblot analysis of podocyte damage-related protein in high glucose (HG) induced podocytes.β-actin served as a loading control

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Human Genomics

ISSN: 1479-7364