Fig. 2

Variants filtering strategy. *The Strand-biased variants refer to the variants whose forward and reverse stranded alternative counts have a ratio of either 2:8 or 8:2. ^†The Panel of Normals approach was used to determine the selection criteria for variants for somatic variants, with a threshold of variant frequency (refer to https://gatk.broadinstitute.org/hc/en-us/articles/360035890631-Panel-of-Normals-PON-). VAF Variant allele frequency; MAF Minor allele frequency; gnsomAD The genome aggregation database; KOVA Korean variant archive; KRGDB Korean reference genome database; DM Disease-causing variant, HGMD The human gene variant database; gnomAD_genome/exome_ALL; gnomAD_genome/exome_EAS, The allele frequencies from all populations and East Asian population, respectively through genome/exome sequencing