Table 3 Frequencies of inferred CYP2C9 metabolizer phenotype
Country | NM (in %) | IM (in %) | PM (in %) |
|---|---|---|---|
Europe | |||
South Europe | |||
Bulgaria | 64.0 | 33.6 | 2.4 |
Croatia | 54.8 | 41.2 | 4.0 |
Greek | 62.4 | 34.9 | 2.8 |
Italy | 61.2 | 35.6 | 3.2 |
North Macedonia | 64.9 | 32.9 | 2.3 |
Portugal | 62.1 | 35.2 | 2.8 |
Serbia | 63.7 | 33.7 | 2.6 |
Spain | 58.0 | 38.2 | 3.8 |
Turkey | 63.5 | 33.5 | 3.0 |
North Europe | |||
Denmark | 68.2 | 30.2 | 1.6 |
Estonia | 71.1 | 27.1 | 1.7 |
Finland | 67.8 | 30.4 | 1.8 |
Norway | 69.9 | 28.4 | 1.7 |
Sweden | 67.0 | 31.1 | 1.9 |
Central and East Europe | |||
Czech | 68.2 | 30.1 | 1.7 |
Germany | 65.6 | 32.7 | 1.7 |
Hungary | 61.9 | 35.1 | 3.0 |
Romania | 63.0 | 34.0 | 3.0 |
Russian | 68.6 | 29.6 | 1.9 |
Slovak | 67.2 | 30.5 | 2.2 |
Slovenia | 66.4 | 31.6 | 1.9 |
West Europe | |||
Belgium | 67.6 | 30.3 | 2.1 |
France | 59.3 | 37.7 | 3.0 |
Netherlands | 65.6 | 32.5 | 1.9 |
UK | 70.8 | 27.7 | 1.5 |
Africa | |||
Benin | 91.2 | 8.8 | 0.0 |
Egypt | 67.2 | 31.0 | 1.8 |
Ethiopia | 78.3 | 21.0 | 0.6 |
Gambia | 99.2 | 0.8 | 0.0 |
Ghana | 100.0 | 0.0 | 0.0 |
Morocco | 81.9 | 18.1 | 0.0 |
Mozambique | 64.2 | 35.5 | 0.4 |
Nigeria | 100.0 | 0.0 | 0.0 |
Sudan | 82.8 | 16.9 | 0.3 |
Middle East | |||
Iran | 56.9 | 40.3 | 2.8 |
Israel | 60.0 | 37.0 | 3.0 |
Jordan | 63.5 | 34.2 | 2.3 |
Kuwaiti | 65.6 | 32.7 | 1.7 |
Lebanon | 59.0 | 38.0 | 3.0 |
Oman | 79.9 | 19.5 | 0.6 |
Saudi Arabia | 66.1 | 31.9 | 2.0 |
United Arab Emirates | 40.2 | 48.7 | 11.1 |
ASIA | |||
Southeast Asia | |||
Indonesia | 95.3 | 4.7 | 0.1 |
Malay | 92.4 | 7.5 | 0.1 |
Thai | 89.6 | 10.1 | 0.3 |
Vietnam | 94.2 | 5.7 | 0.1 |
East Asia | |||
Bhutan | 99.3 | 0.7 | 0.0 |
China | 92.9 | 7.8 | 0.2 |
Japan | 95.2 | 4.8 | 0.1 |
Korea | 97.8 | 3.0 | 0.0 |
South Asia | |||
Bangladesh | 75.2 | 23.1 | 1.7 |
Indian | 74.3 | 24.0 | 1.7 |
Pakistani | 69.0 | 28.4 | 2.6 |
South America | |||
Argentina | 89.1 | 10.6 | 0.3 |
Bolivia | 85.0 | 14.6 | 0.4 |
Brazil | 62.6 | 35.2 | 2.1 |
Chile | 75.7 | 23.4 | 0.9 |
Columbia | 70.4 | 27.9 | 1.7 |
Ecuador | 91.8 | 8.0 | 0.2 |
Peru | 84.3 | 15.2 | 0.5 |
Uruguay | 63.0 | 34.4 | 2.6 |
Venezuela | 81.6 | 18.0 | 0.4 |
North America | |||
Costa Rica | 85.5 | 14.1 | 0.3 |
Cuba | 62.4 | 34.6 | 3.0 |
Mexico | 87.6 | 12.2 | 0.3 |
Oceania | |||
Australia | 64.5 | 33.3 | 2.2 |