Table 4 Genetic patterns analysis of APP in Guizhou Han population
SNP | Nation | Genetic patterns | Genotype | Control group | EH group | OR (95% CI) | P | Adjusted OR (95% CI)a | P |
|---|---|---|---|---|---|---|---|---|---|
rs2211772 | Han population | Codominat | TT | 53 (50%) | 64 (56%) | 1 | 1 | ||
TC | 46 (43%) | 49 (43%) | 0.882 (0.513–1.518) | 0.651 | 0.955 (0.536–1.700) | 0.875 | |||
CC | 8 (7%) | 1 (1%) | 0.104 (0.013–0.854) | 0.035 | 0.103 (0.012–0.908) | 0.041 | |||
Dominant | TT | 53 (50%) | 64 (56%) | 1 | 1 | ||||
TC-CC | 54 (50%) | 50 (44%) | 0.767 (0.452–1.302) | 0.326 | 0.815 (0.466–1.428) | 0.476 | |||
Recessive | TT-TC | 99 (93%) | 113 (99%) | 1 | 1 | ||||
CC | 8 (7%) | 1 (1%) | 0.11 (0.013–0.891) | 0.039 | 0.105 (0.012–0.914) | 0.041 | |||
Overdominant | TT-CC | 61 (57%) | 65 (57%) | 1 | 1 | ||||
TC | 46 (43%) | 49 (43%) | 1.00 (0.587–1.703) | 0.999 | 1.07 (0.606–1.887) | 0.816 | |||
Log-additive | – | – | – | 0.669 (0.42–1.065) | 0.09 | 0.701 (0.43–1.143) | 0.154 | ||
rs2040273 | Miao population | Codominat | AA | 31 (28%) | 46 (42%) | 1 | 1 | ||
AG | 58 (52%) | 47 (43%) | 0.546 (0.301–0.991) | 0.047 | 0.527 (0.28–0.991) | 0.047 | |||
GG | 22 (20%) | 17 (15%) | 0.521 (0.239–1.136) | 0.101 | 0.549 (0.24–1.259) | 0.157 | |||
Dominant | AA | 31 (28%) | 46 (42%) | 1 | 1 | ||||
AG-GG | 80 (72%) | 64 (58%) | 0.539 (0.307–0.945) | 0.031 | 0.533 (0.294–0.965) | 0.038 | |||
Recessive | AA-AG | 89 (80%) | 93 (85%) | 1 | 1 | ||||
GG | 22 (20%) | 17 (15%) | 0.739 (0.369–1.484) | 0.396 | 0.791 (0.376–1.664) | 0.537 | |||
Overdominant | AA-GG | 53 (48%) | 63 (57%) | 1 | 1 | ||||
AG | 58 (52%) | 47 (43%) | 0.682 (0.401–1.159) | 0.157 | 0.642 (0.364–1.131) | 0.125 | |||
Log-additive | – | – | – | 0.689 (0.47–1.008) | 0.055 | 0.699 (0.466–1.046) | 0.082 |