Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study

Table 6 Methylation levels of CpG sites in APP gene promoter region

CpG sites	Position (negative chain)	Methylation level [Median, IQR (P25, P75)]		z	P
CpG sites	Position (negative chain)	Control group (n = 59)	EH group (n = 60)	z	P
CpG_1	− 296 bp	0.17, 0.17 (0.08, 0.25)	0.12, 0.13 (0.07, 0.20)	− 1.662	0.096
CpG_2	− 316 bp	0.00, 0.00 (0.00, 0.00)	0.00, 0.00 (0.00, 0.00)	− 0.022	0.983
CpG_3_4_5	− 322 bp/− 332 bp/− 338 bp	0.11, 0.05 (0.08, 0.13)	0.11, 0.06 (0.08, 0.14)	− 0.837	0.402
CpG_6_16	− 355 bp/− 551 bp	0.00, 0.07 (0.00, 0.07)	0.00, 0.01 (0.00, 0.01)	− 1.603	0.109
CpG_7	− 361 bp	0.06, 0.08 (0.02, 0.10)	0.07, 0.06 (0.03, 0.09)	− 0.016	0.987
CpG_8_9	− 372 bp/− 381 bp	0.04, 0.03 (0.03, 0.06)	0.04, 0.02 (0.03, 0.05)	− 0.858	0.391
CpG_10	− 406 bp	0.02, 0.02 (0.01, 0.03)	0.01, 0.02 (0.00, 0.02)	− 2.024	0.043
CpG_11	− 416 bp	0.44, 0.29 (0.31, 0.60)	0.38, 0.28 (0.28, 0.56)	− 0.968	0.333
CpG_14	− 457 bp	0.04, 0.03 (0.03, 0.06)	0.04, 0.02 (0.03, 0.05)	− 1.04	0.298
CpG_19	− 613 bp	0.58, 0.16 (0.47, 0.63)	0.61, 0.11 (0.57, 0.68)	− 2.721	0.007
CpG_20	− 633 bp	0.67, 0.12 (0.65, 0.72)	0.67, 0.07 (0.63, 0.70)	− 1.068	0.285

Bold indicates P < 0.05
Quantitative skewed data are represented by Median (IQR), and comparisons between groups are performed using the Mann–Whitney test

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