Skip to main content
Fig. 2 | Human Genomics

Fig. 2

From: Controlling the confounding effect of metabolic gene expression to identify actual metabolite targets in microsatellite instability cancers

Fig. 2

Adjusted metabolite features with confounding covariates in MSI and MSS cancers. The heatmap illustrates the relationship between adjusted metabolite features and microsatellite instability (MSI)/microsatellite stable (MSS) cancer status. In the CATCH model, the Y-axis displays adjusted metabolite features and levels. Eight crucial adjusted metabolite features were found to distinguish between MSI and MSS cancers. The cancer cell lineages (gastrointestinal (GI), breast, and gynecologic (GYN), hematologic (Hema), genitourinary (GU), and others), MSI/MSS cancer status, and APC and TP53 mutations (mutation/wild type: M/W) are displayed on the X-axis. Positive values for adjusted metabolite features suggest a stronger association with MSI cancers, while negative values represent a strong association with MSS cancer. The eight different metabolite features were Hippurate, 3-phosphoglycerate, cholesterol ester (CE, C14:0), lysophosphatidylethanolamine (LPE, C18:0), 6-phosphogluconate, phosphatidylcholine (PC, C36:1), reduced glutathione (GSH), and sarcosine

Back to article page

Human Genomics

ISSN: 1479-7364