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Fig. 5 | Human Genomics

Fig. 5

From: Controlling the confounding effect of metabolic gene expression to identify actual metabolite targets in microsatellite instability cancers

Fig. 5

Metabolic pathways in MSI and MSS cancers. MSI cancer cells exhibit glycolytic metabolism, including the serine synthesis (sarcosine synthesis) and pentose phosphate (nucleotide synthesis) pathways. Sarcosine, 3-phosphoglycerate, and 6-phosphogluconate levels were elevated. Additionally, lipid metabolism and GSH synthesis were observed in MSI cancer metabolism. Levels of PC, LPE, CE, and GSH were elevated. Phosphofructokinase 1 (PFKP), ALDH4A1, GPT2, and CHPT1 are involved in MSI cancer metabolism. These metabolic pathways promote cancer cell proliferation, energy production, and survival. DNA repair genetic mutations drive cancer metabolism, and sarcosine damages the DNA. Sarcosine and genomic alterations can regulate each other. In MSS cancers, environmental factors, such as the microbiota, may play a crucial role in Hippurate synthesis

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Human Genomics

ISSN: 1479-7364