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Fig. 10 | Human Genomics

Fig. 10

From: Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression

Fig. 10

LINC00945 promotes EMT, migration, and invasion of glioma cells. A, B Morphological changes were perceived in both LN18 (A) and PN12 (B) cells after culturing for three weeks following overexpression LINC00945. C–E The expression of LINC00945 was positively correlated with the expression of N-cadherin (C), ZEB1 (D), and ZEB2 (E) in the TCGA database. F, G The mRNA expression levels of EMT-related genes (N-cadherin, ZEB1, and ZEB2) in LN18 (F) and PN12 (G) glioma cells transfected with LINC00945 and vector plasmids were examined by qRT-PCR. H, I Western blot examined the different expression levels of N-cadherin, ZEB1, and ZEB2 proteins in the LINC00945 overexpression and vector groups. J, K Transwell experiments revealed that overexpression of LINC00945 promoted LN18 and PN12 glioma cell migration (J) and invasion (K). ***p < 0.001. The independent biological experiments were repeated at least three times

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Human Genomics

ISSN: 1479-7364